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    Nusap1 nucleolar and spindle associated protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 108907, updated on 24-Dec-2024

    Summary

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    Official Symbol
    Nusap1provided by MGI
    Official Full Name
    nucleolar and spindle associated protein 1provided by MGI
    Primary source
    MGI:MGI:2675669
    See related
    Ensembl:ENSMUSG00000027306 AllianceGenome:MGI:2675669
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LNP; ANKT; SAPL; BM037; NuSAP; Q0310; 2610201A12Rik
    Summary
    Enables microtubule binding activity. Predicted to be involved in establishment of mitotic spindle localization; mitotic chromosome condensation; and mitotic cytokinesis. Predicted to act upstream of or within mitotic sister chromatid segregation and positive regulation of mitotic nuclear division. Located in nucleolus. Is active in mitotic spindle. Is expressed in several structures, including genitourinary system; gut; immune system; respiratory system; and skin. Orthologous to human NUSAP1 (nucleolar and spindle associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver E14 (RPKM 34.2), liver E14.5 (RPKM 28.2) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nusap1 in Genome Data Viewer
    Location:
    2 E5; 2 59.97 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (119449205..119480646)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (119618298..119650165)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1008 Neighboring gene Opa interacting protein 5, opposite strand 1 Neighboring gene Opa interacting protein 5 Neighboring gene STARR-positive B cell enhancer mm9_chr2:119444191-119444492 Neighboring gene nuclear encoded rRNA 5S 204 Neighboring gene STARR-positive B cell enhancer ABC_E3395 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E9201 Neighboring gene H3 histone, family 3C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. NUSAP1 regulates mouse oocyte meiotic maturation. Yu L, et al. J Cell Biochem, 2023 Dec. PMID 37992207
    2. A role for NuSAP in linking microtubules to mitotic chromosomes. Ribbeck K, et al. Curr Biol, 2007 Feb 6. PMID 17276916
    3. ATM-mediated NuSAP phosphorylation induces mitotic arrest. Xie P, et al. Biochem Biophys Res Commun, 2011 Jan 7. PMID 21130744
    4. SAP-like domain in nucleolar spindle associated protein mediates mitotic chromosome loading as well as interphase chromatin interaction. Verbakel W, et al. Biochem Biophys Res Commun, 2011 Aug 12. PMID 21782797
    5. NuSAP, a novel microtubule-associated protein involved in mitotic spindle organization. Raemaekers T, et al. J Cell Biol, 2003 Sep 15. PMID 12963707, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in establishment of mitotic spindle localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within establishment of mitotic spindle localization ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in mitotic chromosome condensation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within mitotic chromosome condensation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in mitotic cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within mitotic cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within mitotic sister chromatid segregation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of mitotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nucleolar and spindle-associated protein 1
    Names
    nucleolar protein ANKT

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042652.2 → NP_001036117.1  nucleolar and spindle-associated protein 1 isoform b

      See identical proteins and their annotated locations for NP_001036117.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame segment, compared to variant 1, resulting in a shorter protein (isoform b), compared to isoform a.
      Source sequence(s)
      AL844536
      Consensus CDS
      CCDS38206.1
      UniProtKB/Swiss-Prot
      Q9ERH4
      Related
      ENSMUSP00000028771.8, ENSMUST00000028771.8
      Conserved Domains (1) summary
      pfam16006
      Location:161 → 388
      NUSAP; Nucleolar and spindle-associated protein

    2. NM_133851.4 → NP_598612.1  nucleolar and spindle-associated protein 1 isoform a

      See identical proteins and their annotated locations for NP_598612.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform a).
      Source sequence(s)
      AL844536
      Consensus CDS
      CCDS16605.1
      UniProtKB/Swiss-Prot
      Q8C2L8, Q8C989, Q921Z0, Q9ERH4
      Related
      ENSMUSP00000068713.9, ENSMUST00000068225.15
      Conserved Domains (1) summary
      pfam16006
      Location:170 → 421
      NUSAP; Nucleolar and spindle-associated protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      119449205..119480646
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246564.2 → XP_030102424.1  nucleolar and spindle-associated protein 1 isoform X1

      Conserved Domains (1) summary
      pfam16006
      Location:40 → 269
      NUSAP; Nucleolar and spindle-associated protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ERH4.1 GenPept UniProtKB/Swiss-Prot:Q9ERH4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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