Folr1 folate receptor alpha [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Folr1provided by MGI
Official Full Name: folate receptor alphaprovided by MGI
Primary source: MGI:MGI:95568
See related: Ensembl:ENSMUSG00000001827 AllianceGenome:MGI:95568
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FBP1; Folbp1; Folbp-1
Summary: Predicted to enable folic acid binding activity; folic acid receptor activity; and signaling receptor activity. Involved in circulatory system development; nervous system development; and regulation of signal transduction. Acts upstream of or within folic acid metabolic process. Predicted to be located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and brush border membrane. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including brain; early conceptus; genitourinary system; gut; and retina. Human ortholog(s) of this gene implicated in cerebral folate receptor alpha deficiency. Orthologous to human FOLR1 (folate receptor alpha). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in kidney adult (RPKM 188.9), placenta adult (RPKM 82.7) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 7 E2; 7 54.67 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (101507551..101519974, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (101858331..101870788, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role of folate receptor alpha in the partial rejuvenation of dentate gyrus cells: Improvement of cognitive function in 21-month-old aged mice.
Title: Role of folate receptor α in the partial rejuvenation of dentate gyrus cells: Improvement of cognitive function in 21-month-old aged mice.
Elevated expression of receptors for EGF, PDGF, transferrin and folate within murine and human lupus nephritis kidneys.
Title: Elevated expression of receptors for EGF, PDGF, transferrin and folate within murine and human lupus nephritis kidneys.
Gestational folate deficiency alters embryonic gene expression and cell function.
Title: Gestational folate deficiency alters embryonic gene expression and cell function.
Several experimental studies in mice and human epidemiological and genetics studies have suggested that FOLR1 abnormalities are involved in a portion of human neural tube defects (NTD), although the solo defect of FOLR1 did not cause NTD. (Review)
Title: Folate receptors and neural tube closure.
Midbrain dopamine neural progenitors and nascent dopamine neurons specifically express Folr1.
Title: FolR1: a novel cell surface marker for isolating midbrain dopamine neural progenitors and nascent dopamine neurons.
The above showed that human FRalpha based DNA vaccination with CpG oligodeoxynucleotides as an adjuvant was effective in growth inhibition of a FRalpha expressing tumor in mice and deserves further evaluation as a possible immunotherapy
Title: CpG oligodeoxynucleotides augment antitumor efficacy of folate receptor α based DNA vaccine.
Folate receptor alpha upregulates Oct4, Sox2 and Klf4 and downregulates miR-138 and miR-let-7 in cranial neural crest cells.
Title: Folate Receptor Alpha Upregulates Oct4, Sox2 and Klf4 and Downregulates miR-138 and miR-let-7 in Cranial Neural Crest Cells.
not detected in oocytes
Title: Growing Mouse Oocytes Transiently Activate Folate Transport via Folate Receptors As They Approach Full Size.
Folate receptor expression on murine and human adipose tissue macrophages
Title: Folate receptor expression on murine and human adipose tissue macrophages.
Quantitative RT-PCR showed that Slc19a1 mRNA was expressed in mouse cumulus-oocyte complexes (COCs) and oocytes, whereas Folr1 showed expression only in preimplantation embryos, increasing from the 2-cell stage onward.
Title: Folate transport in mouse cumulus-oocyte complexes and preimplantation embryos.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (4) 1 citation

General gene information

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Markers

Folr1 (e-PCR), detects polymorphism
- UniSTS:205455

NoName (e-PCR)
- UniSTS:548575

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables folic acid binding	ISO Inferred from Sequence Orthology more info
enables folic acid binding	ISS Inferred from Sequence or Structural Similarity more info
enables folic acid binding	TAS Traceable Author Statement more info	PubMed
enables folic acid receptor activity	ISO Inferred from Sequence Orthology more info
enables folic acid receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables folic acid receptor activity	TAS Traceable Author Statement more info	PubMed
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in anterior neural tube closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardiac neural crest cell migration involved in outflow tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to folic acid	IEA Inferred from Electronic Annotation more info
involved_in cellular response to folic acid	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within folic acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in folic acid transport	ISO Inferred from Sequence Orthology more info
involved_in folic acid transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in fusion of sperm to egg plasma membrane involved in single fertilization	IBA Inferred from Biological aspect of Ancestor more info
involved_in heart looping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neural crest cell migration involved in heart formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pharyngeal arch artery morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within post-translational protein targeting to endoplasmic reticulum membrane	TAS Traceable Author Statement more info	PubMed
involved_in regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transforming growth factor beta receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to axon injury	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sperm-egg recognition	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in brush border membrane	IEA Inferred from Electronic Annotation more info
located_in brush border membrane	ISO Inferred from Sequence Orthology more info
located_in clathrin-coated vesicle	IEA Inferred from Electronic Annotation more info
located_in endosome	IEA Inferred from Electronic Annotation more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	TAS Traceable Author Statement more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: folate receptor alpha

Names: FR-alpha; folate receptor 1 (adult); folate-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001252552.2 → NP_001239481.1 folate receptor alpha precursor

See identical proteins and their annotated locations for NP_001239481.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. All 16 variants encode the same protein.

Source sequence(s)

AC167240

Consensus CDS

CCDS21517.1

UniProtKB/Swiss-Prot

P35846, Q9R222

UniProtKB/TrEMBL

A1A4B2

Related

ENSMUSP00000102598.2, ENSMUST00000106985.8

Conserved Domains (1) summary

pfam03024
Location:34 → 209

Folate_rec; Folate receptor family
NM_001252553.2 → NP_001239482.1 folate receptor alpha precursor

See identical proteins and their annotated locations for NP_001239482.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses two different splice sites in the 5' UTR, compared to variant 1. All 16 variants encode the same protein.

Source sequence(s)

AC167240

Consensus CDS

CCDS21517.1

UniProtKB/Swiss-Prot

P35846, Q9R222

UniProtKB/TrEMBL

A1A4B2

Conserved Domains (1) summary

pfam03024
Location:34 → 209

Folate_rec; Folate receptor family
NM_001252554.2 → NP_001239483.1 folate receptor alpha precursor

See identical proteins and their annotated locations for NP_001239483.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) uses a different splice site in the 5' UTR, compared to variant 1. All 16 variants encode the same protein.

Source sequence(s)

AC167240

Consensus CDS

CCDS21517.1

UniProtKB/Swiss-Prot

P35846, Q9R222

UniProtKB/TrEMBL

A1A4B2

Related

ENSMUSP00000102596.2, ENSMUST00000106983.8

Conserved Domains (1) summary

pfam03024
Location:34 → 209

Folate_rec; Folate receptor family
NM_001412428.1 → NP_001399357.1 folate receptor alpha precursor

Status: VALIDATED

Source sequence(s)

AC167240

UniProtKB/Swiss-Prot

P35846, Q9R222

UniProtKB/TrEMBL

A1A4B2
NM_001412429.1 → NP_001399358.1 folate receptor alpha precursor

Status: VALIDATED

Source sequence(s)

AC167240

UniProtKB/Swiss-Prot

P35846, Q9R222

UniProtKB/TrEMBL

A1A4B2
NM_001412430.1 → NP_001399359.1 folate receptor alpha precursor

Status: VALIDATED

Source sequence(s)

AC167240

UniProtKB/Swiss-Prot

P35846, Q9R222

UniProtKB/TrEMBL

A1A4B2
NM_001412431.1 → NP_001399360.1 folate receptor alpha precursor

Status: VALIDATED

Source sequence(s)

AC167240

UniProtKB/Swiss-Prot

P35846, Q9R222

UniProtKB/TrEMBL

A1A4B2
NM_001412432.1 → NP_001399361.1 folate receptor alpha precursor

Status: VALIDATED

Source sequence(s)

AC167240

UniProtKB/Swiss-Prot

P35846, Q9R222

UniProtKB/TrEMBL

A1A4B2
NM_001412433.1 → NP_001399362.1 folate receptor alpha precursor

Status: VALIDATED

Source sequence(s)

AC167240

UniProtKB/Swiss-Prot

P35846, Q9R222

UniProtKB/TrEMBL

A1A4B2
NM_001412434.1 → NP_001399363.1 folate receptor alpha precursor

Status: VALIDATED

Source sequence(s)

AC167240

UniProtKB/Swiss-Prot

P35846, Q9R222

UniProtKB/TrEMBL

A1A4B2
NM_001412435.1 → NP_001399364.1 folate receptor alpha precursor

Status: VALIDATED

Source sequence(s)

AC167240

UniProtKB/Swiss-Prot

P35846, Q9R222

UniProtKB/TrEMBL

A1A4B2
NM_001412436.1 → NP_001399365.1 folate receptor alpha precursor

Status: VALIDATED

Source sequence(s)

AC167240

UniProtKB/Swiss-Prot

P35846, Q9R222

UniProtKB/TrEMBL

A1A4B2

Related

ENSMUSP00000102595.2, ENSMUST00000106982.8
NM_001412437.1 → NP_001399366.1 folate receptor alpha precursor

Status: VALIDATED

Source sequence(s)

AC167240

UniProtKB/Swiss-Prot

P35846, Q9R222

UniProtKB/TrEMBL

A1A4B2
NM_001412438.1 → NP_001399367.1 folate receptor alpha precursor

Status: VALIDATED

Source sequence(s)

AC167240

UniProtKB/Swiss-Prot

P35846, Q9R222

UniProtKB/TrEMBL

A1A4B2
NM_001412439.1 → NP_001399368.1 folate receptor alpha precursor

Status: VALIDATED

Source sequence(s)

AC167240

UniProtKB/Swiss-Prot

P35846, Q9R222

UniProtKB/TrEMBL

A1A4B2

Related

ENSMUSP00000102594.2, ENSMUST00000106981.8
NM_008034.4 → NP_032060.2 folate receptor alpha precursor

See identical proteins and their annotated locations for NP_032060.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses a different splice site in the 5' UTR, compared to variant 1. All 16 variants encode the same protein.

Source sequence(s)

AC167240

Consensus CDS

CCDS21517.1

UniProtKB/Swiss-Prot

P35846, Q9R222

UniProtKB/TrEMBL

A1A4B2

Related

ENSMUSP00000102599.3, ENSMUST00000106986.9

Conserved Domains (1) summary

pfam03024
Location:34 → 209

Folate_rec; Folate receptor family