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    Plgrkt plasminogen receptor, C-terminal lysine transmembrane protein [ Mus musculus (house mouse) ]

    Gene ID: 67759, updated on 23-Dec-2024

    Summary

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    Official Symbol
    Plgrktprovided by MGI
    Official Full Name
    plasminogen receptor, C-terminal lysine transmembrane proteinprovided by MGI
    Primary source
    MGI:MGI:1915009
    See related
    Ensembl:ENSMUSG00000016495 AllianceGenome:MGI:1915009
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Plg-RKT; Plg-R(KT); 1110007H22Rik; 5033414D02Rik
    Summary
    Acts upstream of or within positive regulation of plasminogen activation. Located in plasma membrane. Is expressed in thymus primordium. Orthologous to human PLGRKT (plasminogen receptor with a C-terminal lysine). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 21.8), thymus adult (RPKM 10.8) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Plgrkt in Genome Data Viewer
    Location:
    19 C1; 19 23.85 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (29326004..29339340, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (29348599..29367292, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene insulin-like 6 Neighboring gene predicted gene, 52390 Neighboring gene relaxin 1 Neighboring gene STARR-positive B cell enhancer ABC_E9996 Neighboring gene STARR-positive B cell enhancer ABC_E3250 Neighboring gene STARR-positive B cell enhancer ABC_E5694 Neighboring gene CD274 antigen Neighboring gene predicted gene, 36043 Neighboring gene STARR-positive B cell enhancer mm9_chr19:29465786-29466087 Neighboring gene STARR-seq mESC enhancer starr_45884 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:29493177-29493330 Neighboring gene programmed cell death 1 ligand 2 Neighboring gene STARR-positive B cell enhancer mm9_chr19:29505524-29505825 Neighboring gene STARR-seq mESC enhancer starr_45885 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:29528717-29528916

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Exposure of plasminogen and a novel plasminogen receptor, Plg-RKT, on activated human and murine platelets. Whyte CS, et al. Blood, 2021 Jan 14. PMID 32842150, Free PMC Article
    2. The plasminogen receptor Plg-R(KT) regulates adipose function and metabolic homeostasis. Samad F, et al. J Thromb Haemost, 2022 Mar. PMID 34897983, Free PMC Article
    3. The plasminogen receptor(,) Plg-R(KT)(,) is essential for mammary lobuloalveolar development and lactation. Miles LA, et al. J Thromb Haemost, 2018 May. PMID 29495105, Free PMC Article
    4. Deficiency of plasminogen receptor, Plg-R(KT) , causes defects in plasminogen binding and inflammatory macrophage recruitment in vivo. Miles LA, et al. J Thromb Haemost, 2017 Jan. PMID 27714956, Free PMC Article
    5. The plasminogen receptor, Plg-R(KT), plays a role in inflammation and fibrinolysis during cutaneous wound healing in mice. Ny L, et al. Cell Death Dis, 2020 Dec 12. PMID 33311441, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The plasminogen receptor Plg-RKT regulates adipose function and metabolic homeostasis.
      Title: The plasminogen receptor Plg-R(KT) regulates adipose function and metabolic homeostasis.
    2. Exposure of plasminogen and a novel plasminogen receptor, Plg-RKT, on activated human and murine platelets.
      Title: Exposure of plasminogen and a novel plasminogen receptor, Plg-RKT, on activated human and murine platelets.
    3. The plasminogen receptor, Plg-RKT, plays a role in inflammation and fibrinolysis during cutaneous wound healing in mice.
      Title: The plasminogen receptor, Plg-R(KT), plays a role in inflammation and fibrinolysis during cutaneous wound healing in mice.
    4. Plasminogen and the Plasminogen Receptor, Plg-RKT, Regulate Macrophage Phenotypic, and Functional Changes.
      Title: Plasminogen and the Plasminogen Receptor, Plg-R(KT), Regulate Macrophage Phenotypic, and Functional Changes.
    5. Plg-RKT is essential for lactogenesis and functions to maintain the appropriate stromal extracellular matrix environment, regulate epithelial cell proliferation and apoptosis, and, by regulating fibrinolysis, preserve alveolar and ductal patency.
      Title: The plasminogen receptor(,) Plg-R(KT)(,) is essential for mammary lobuloalveolar development and lactation.
    6. Plg-R(KT) was highly expressed in bovine adrenomedullary chromaffin cells, human pheochromocytoma tissue, PC12 pheochromocytoma cells, and murine hippocampus.
      Title: The novel plasminogen receptor, plasminogen receptor(KT) (Plg-R(KT)), regulates catecholamine release.
    7. Plg-R(KT) plays a key role in the plasminogen-dependent regulation of macrophage invasion, chemotactic migration, and recruitment in the inflammatory response.
      Title: Regulation of macrophage migration by a novel plasminogen receptor Plg-R KT.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of plasminogen activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of plasminogen activation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    plasminogen receptor (KT)
    Names
    transmembrane protein C9orf46 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026362.2 → NP_080638.1  plasminogen receptor (KT)

      See identical proteins and their annotated locations for NP_080638.1

      Status: VALIDATED

      Source sequence(s)
      AK017215
      Consensus CDS
      CCDS29734.1
      UniProtKB/Swiss-Prot
      Q3TCJ3, Q9D3P8
      Related
      ENSMUSP00000120466.2, ENSMUST00000143467.8
      Conserved Domains (1) summary
      pfam10166
      Location:1 → 134
      DUF2368; Uncharacterized conserved protein (DUF2368)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      29326004..29339340 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251060.2 → XP_030106920.1  plasminogen receptor (KT) isoform X1

      UniProtKB/Swiss-Prot
      Q3TCJ3, Q9D3P8
      Conserved Domains (1) summary
      pfam10166
      Location:1 → 134
      DUF2368; Uncharacterized conserved protein (DUF2368)

    2. XM_030251059.2 → XP_030106919.1  plasminogen receptor (KT) isoform X1

      UniProtKB/Swiss-Prot
      Q3TCJ3, Q9D3P8
      Related
      ENSMUSP00000016639.6, ENSMUST00000016639.12
      Conserved Domains (1) summary
      pfam10166
      Location:1 → 134
      DUF2368; Uncharacterized conserved protein (DUF2368)

    3. XM_030251058.2 → XP_030106918.1  plasminogen receptor (KT) isoform X1

      UniProtKB/Swiss-Prot
      Q3TCJ3, Q9D3P8
      Conserved Domains (1) summary
      pfam10166
      Location:1 → 134
      DUF2368; Uncharacterized conserved protein (DUF2368)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D3P8.1 GenPept UniProtKB/Swiss-Prot:Q9D3P8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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