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    rom-4 Peptidase S54 rhomboid domain-containing protein;Rhomboid-like protein [ Caenorhabditis elegans ]

    Gene ID: 3565076, updated on 9-Dec-2024

    Summary

    Official Symbol
    rom-4
    Official Full Name
    Peptidase S54 rhomboid domain-containing protein;Rhomboid-like protein
    Primary source
    WormBase:WBGene00004403
    Locus tag
    CELE_Y116A8C.16
    See related
    AllianceGenome:WB:WBGene00004403
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in regulation of epidermal growth factor receptor signaling pathway and regulation of protein secretion. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in palmoplantar keratoderma-esophageal carcinoma syndrome. Orthologous to human RHBDF1 (rhomboid 5 homolog 1) and RHBDF2 (rhomboid 5 homolog 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See rom-4 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    14
    Sequence:
    Chromosome: IV; NC_003282.8 (16995822..17014953)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Component Evidence Code Pubs
    located_in endoplasmic reticulum  
    is_active_in endoplasmic reticulum membrane  
    located_in endoplasmic reticulum membrane  
    located_in membrane  

    General protein information

    Preferred Names
    Peptidase S54 rhomboid domain-containing protein;Rhomboid-like protein
    NP_001041013.2
    • Confirmed by transcript evidence
    NP_001041014.1
    • Confirmed by transcript evidence
    NP_001076719.2
    • Confirmed by transcript evidence
    NP_001263830.1
    • Confirmed by transcript evidence
    NP_001368544.1
    • Confirmed by transcript evidence
    NP_001368545.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      16995822..17014953
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001047548.5NP_001041013.2  Peptidase S54 rhomboid domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001041013.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U2V5
      Conserved Domains (1) summary
      pfam01694
      Location:9251066
      Rhomboid; Rhomboid family
    2. NM_001083250.6NP_001076719.2  Peptidase S54 rhomboid domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001076719.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KML1
      Conserved Domains (1) summary
      pfam01694
      Location:9271068
      Rhomboid; Rhomboid family
    3. NM_001380564.1NP_001368544.1  Peptidase S54 rhomboid domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AXE4
      Conserved Domains (1) summary
      pfam01694
      Location:608748
      Rhomboid; Rhomboid family
    4. NM_001047549.4NP_001041014.1  Rhomboid-like protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001041014.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2YS42
    5. NM_001380565.1NP_001368545.1  Peptidase S54 rhomboid domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AS30
      Conserved Domains (1) summary
      pfam01694
      Location:326466
      Rhomboid; Rhomboid family
    6. NM_001276901.3NP_001263830.1  Rhomboid-like protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001263830.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      I2HAL3
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