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    avr-15 Ig-like domain-containing protein;Neurotransmitter-gated ion-channel transmembrane domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179834, updated on 9-Dec-2024

    Summary

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    Official Symbol
    avr-15
    Official Full Name
    Ig-like domain-containing protein;Neurotransmitter-gated ion-channel transmembrane domain-containing protein
    Primary source
    WormBase:WBGene00000233
    Locus tag
    CELE_R11G10.1
    See related
    AllianceGenome:WB:WBGene00000233
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable excitatory extracellular ligand-gated monoatomic ion channel activity and neurotransmitter receptor activity. Predicted to contribute to chloride channel activity. Involved in action potential; locomotion involved in locomotory behavior; and regulation of nematode pharyngeal pumping. Predicted to be located in membrane and postsynapse. Predicted to be part of transmembrane transporter complex. Predicted to be active in neuron projection; plasma membrane; and synapse. Is expressed in motor neurons; pharynx; preanal ganglion neurons; somatic nervous system; and in male. Human ortholog(s) of this gene implicated in hyperekplexia 2 and syndromic X-linked intellectual disability Pilorge type. Orthologous to human GLRA2 (glycine receptor alpha 2); GLRA3 (glycine receptor alpha 3); and GLRB (glycine receptor beta). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See avr-15 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    8
    Sequence:
    Chromosome: V; NC_003283.11 (13498780..13511718, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Abnormal cell migration protein 18-like fibronectin type I domain-containing protein Neighboring gene FYVE-type domain-containing protein Neighboring gene U6 snRNA-associated Sm-like protein LSm2 Neighboring gene FIP (Fungus-Induced Protein) Related Neighboring gene tRNA-Pro Neighboring gene tRNA-Pro Neighboring gene Putative selenium-binding protein Neighboring gene Serpentine Receptor, class Z Neighboring gene pseudo Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Glutamate-gated Cl- channels in Caenorhabditis elegans and parasitic nematodes. Wolstenholme AJ. Biochem Soc Trans, 1997 Aug. PMID 9388555
    2. Characterization of glutamate-gated chloride channels in the pharynx of wild-type and mutant Caenorhabditis elegans delineates the role of the subunit GluCl-alpha2 in the function of the native receptor. Pemberton DJ, et al. Mol Pharmacol, 2001 May. PMID 11306685
    3. Effect of refrigeration on the antinematodal efficacy of ivermectin. O'Lone RB, et al. J Parasitol, 2001 Apr. PMID 11318586
    4. The Validation of Nematode-Specific Acetylcholine-Gated Chloride Channels as Potential Anthelmintic Drug Targets. Wever CM, et al. PLoS One, 2015. PMID 26393923, Free PMC Article
    5. Quantifying the fitness effects of resistance alleles with and without anthelmintic selection pressure using Caenorhabditis elegans. Shaver AO, et al. PLoS Pathog, 2024 May. PMID 38768235, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    contributes_to chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables excitatory extracellular ligand-gated monoatomic ion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables extracellular ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in action potential IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in locomotion involved in locomotory behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in locomotion involved in locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of nematode pharyngeal pumping IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of nematode pharyngeal pumping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of postsynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ig-like domain-containing protein;Neurotransmitter-gated ion-channel transmembrane domain-containing protein
    NP_001024076.1
    • Confirmed by transcript evidence
    NP_001024077.1
    • Confirmed by transcript evidence
    NP_001256513.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      13498780..13511718 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001028905.8 → NP_001024076.1  Ig-like domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024076.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ECH3, O17547
      Conserved Domains (1) summary
      TIGR00860
      Location:253 → 648
      LIC; Cation transporter family protein

    2. NM_001028906.6 → NP_001024077.1  Ig-like domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024077.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O17548, Q95PJ6
      Conserved Domains (1) summary
      TIGR00860
      Location:74 → 469
      LIC; Cation transporter family protein

    3. NM_001269584.3 → NP_001256513.1  Neurotransmitter-gated ion-channel transmembrane domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256513.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D7SFP2
      Conserved Domains (1) summary
      cd19062
      Location:1 → 170
      LGIC_TM_GluCl; transmembrane domain of glutamate gated chloride channel (GluCl)
    Nucleotide Protein
    Heading Accession and Version

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