sec-22 Vesicle-trafficking protein SEC22b [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: sec-22
Official Full Name: Vesicle-trafficking protein SEC22b
Primary source: WormBase:WBGene00018853
Locus tag: CELE_F55A4.1
See related: AllianceGenome:WB:WBGene00018853
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable SNAP receptor activity. Involved in IRE1-mediated unfolded protein response. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment membrane. Predicted to be part of SNARE complex. Predicted to be active in bounding membrane of organelle; endoplasmic reticulum membrane; and endoplasmic reticulum-Golgi intermediate compartment. Is expressed in several structures, including body wall musculature; pharynx; somatic cell; tail; and vulval muscle. Used to study Parkinson's disease. Orthologous to human SEC22B (SEC22 homolog B, vesicle trafficking protein). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See sec-22 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 5

Sequence:: Chromosome: X; NC_003284.9 (1035548..1037066)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SEC-22 localizes to late endosomes and negatively regulates RNA interference in Caenorhabditis elegans; SEC-22 interacts with late endosome-associated RNA transport protein SID-5 and functions in a SID-5-dependent manner.
Title: The conserved SNARE SEC-22 localizes to late endosomes and negatively regulates RNA interference in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F55A4.1 (e-PCR)
- UniSTS:314460

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables SNAP receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables SNAP receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in IRE1-mediated unfolded protein response	HEP more info	PubMed
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IEA Inferred from Electronic Annotation more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
involved_in vesicle fusion with Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in ER to Golgi transport vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of SNARE complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum-Golgi intermediate compartment membrane	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Vesicle-trafficking protein SEC22b

NP_508198.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

1035548..1037066

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_075797.7 → NP_508198.1 Vesicle-trafficking protein SEC22b [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_508198.1

Status: REVIEWED

UniProtKB/TrEMBL

Q94241

Conserved Domains (3) summary

cd15866
Location:131 → 194

R-SNARE_SEC22; SNARE motif of SEC22

pfam00957
Location:134 → 214

Synaptobrevin; Synaptobrevin

pfam13774
Location:38 → 103

Longin; Regulated-SNARE-like domain