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    zfyv-19 FYVE-type domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179740, updated on 9-Dec-2024

    Summary

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    Official Symbol
    zfyv-19
    Official Full Name
    FYVE-type domain-containing protein
    Primary source
    WormBase:WBGene00011248
    Locus tag
    CELE_R11D1.10
    See related
    AllianceGenome:WB:WBGene00011248
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in abscission and mitotic cytokinesis checkpoint signaling. Predicted to be active in centrosome; cleavage furrow; and midbody. Human ortholog(s) of this gene implicated in progressive familial intrahepatic cholestasis. Orthologous to human ZFYVE19 (zinc finger FYVE-type containing 19). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See zfyv-19 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    7
    Sequence:
    Chromosome: V; NC_003283.11 (12729520..12731794)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene DUF148 domain-containing protein Neighboring gene Large ribosomal subunit protein eL28 Neighboring gene Large ribosomal subunit protein mL49 Neighboring gene L-xylulose reductase Neighboring gene XK-related protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Adult-restricted gene knock-down reveals candidates that affect locomotive healthspan in C. elegans. Jushaj A, et al. Biogerontology, 2023 Apr. PMID 36662373
    2. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
    3. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
    4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in abscission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic cytokinesis checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cleavage furrow IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in midbody IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    FYVE-type domain-containing protein
    NP_506181.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      12729520..12731794
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073780.8 → NP_506181.2  FYVE-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506181.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q21938
      Conserved Domains (1) summary
      cd00065
      Location:6 → 56
      FYVE_like_SF; FYVE domain like superfamily

    RNA

    1. NR_023976.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version

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