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    CCDC159 coiled-coil domain containing 159 [ Homo sapiens (human) ]

    Gene ID: 126075, updated on 27-Dec-2024

    Summary

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    Official Symbol
    CCDC159provided by HGNC
    Official Full Name
    coiled-coil domain containing 159provided by HGNC
    Primary source
    HGNC:HGNC:26996
    See related
    Ensembl:ENSG00000183401 AllianceGenome:HGNC:26996
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to be involved in spermatid development. Predicted to act upstream of or within several processes, including regulation of phosphatase activity; single fertilization; and sperm flagellum assembly. Predicted to be located in sperm head-tail coupling apparatus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis (RPKM 10.3), prostate (RPKM 10.0) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CCDC159 in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (11346519..11354944)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (11473497..11481922)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (11457195..11465620)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene tetraspanin 16 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14008 Neighboring gene RAB3D, member RAS oncogene family Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10107 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:11456465-11457295 Neighboring gene transmembrane protein 205 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11461146-11461646 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10108 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11467020-11467961 Neighboring gene phospholipid phosphatase related 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10109 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14009 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14010 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14011 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14012 Neighboring gene SWIM-type zinc finger 7 associated protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. The DNA sequence and biology of human chromosome 19. Grimwood J, et al. Nature, 2004 Apr 1. PMID 15057824
    2. The sequence of the human genome. Venter JC, et al. Science, 2001 Feb 16. PMID 11181995
    3. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. Lim J, et al. Cell, 2006 May 19. PMID 16713569
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ45351, FLJ79238

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in spermatid development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in sperm head-tail coupling apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    coiled-coil domain-containing protein 159

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080503.3 → NP_001073972.2  coiled-coil domain-containing protein 159

      Status: VALIDATED

      Source sequence(s)
      CA848583, CB241007, DC416232
      Consensus CDS
      CCDS45976.1
      UniProtKB/Swiss-Prot
      B4DEG3, B4DWR8, B4E133, B7ZAM4, P0C7I6
      Related
      ENSP00000402239.1, ENST00000458408.6

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      11346519..11354944
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438148.1 → XP_047294104.1  coiled-coil domain-containing protein 159 isoform X5

    2. XM_017026256.3 → XP_016881745.1  coiled-coil domain-containing protein 159 isoform X2

    3. XM_047438146.1 → XP_047294102.1  coiled-coil domain-containing protein 159 isoform X4

    4. XM_011527678.3 → XP_011525980.2  coiled-coil domain-containing protein 159 isoform X7

    5. XM_017026260.3 → XP_016881749.1  coiled-coil domain-containing protein 159 isoform X9

    6. XM_047438147.1 → XP_047294103.1  coiled-coil domain-containing protein 159 isoform X5

    7. XM_047438149.1 → XP_047294105.1  coiled-coil domain-containing protein 159 isoform X5

    8. XM_017026261.3 → XP_016881750.1  coiled-coil domain-containing protein 159 isoform X11

    9. XM_047438150.1 → XP_047294106.1  coiled-coil domain-containing protein 159 isoform X5

    10. XM_017026255.2 → XP_016881744.1  coiled-coil domain-containing protein 159 isoform X1

    11. XM_006722643.2 → XP_006722706.1  coiled-coil domain-containing protein 159 isoform X3

      Conserved Domains (1) summary
      TIGR00618
      Location:35 → 224
      sbcc; exonuclease SbcC

    12. XM_017026258.3 → XP_016881747.1  coiled-coil domain-containing protein 159 isoform X6

    13. XM_017026259.3 → XP_016881748.1  coiled-coil domain-containing protein 159 isoform X8

    14. XM_024451347.2 → XP_024307115.1  coiled-coil domain-containing protein 159 isoform X10

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      11473497..11481922
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054319762.1 → XP_054175737.1  coiled-coil domain-containing protein 159 isoform X5

    2. XM_054319763.1 → XP_054175738.1  coiled-coil domain-containing protein 159 isoform X5

    3. XM_054319770.1 → XP_054175745.1  coiled-coil domain-containing protein 159 isoform X11

    4. XM_054319764.1 → XP_054175739.1  coiled-coil domain-containing protein 159 isoform X5

    5. XM_054319758.1 → XP_054175733.1  coiled-coil domain-containing protein 159 isoform X1

    6. XM_054319760.1 → XP_054175735.1  coiled-coil domain-containing protein 159 isoform X3

    7. XM_054319765.1 → XP_054175740.1  coiled-coil domain-containing protein 159 isoform X6

    8. XM_054319767.1 → XP_054175742.1  coiled-coil domain-containing protein 159 isoform X8

    9. XM_054319769.1 → XP_054175744.1  coiled-coil domain-containing protein 159 isoform X10

    10. XM_054319766.1 → XP_054175741.1  coiled-coil domain-containing protein 159 isoform X7

    11. XM_054319768.1 → XP_054175743.1  coiled-coil domain-containing protein 159 isoform X9

    12. XM_054319759.1 → XP_054175734.1  coiled-coil domain-containing protein 159 isoform X2

    13. XM_054319761.1 → XP_054175736.1  coiled-coil domain-containing protein 159 isoform X4

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0C7I6.2 GenPept UniProtKB/Swiss-Prot:P0C7I6

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