erl-1 Erlin [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: erl-1
Official Full Name: Erlin
Primary source: WormBase:WBGene00016592
Locus tag: CELE_C42C1.15
See related: AllianceGenome:WB:WBGene00016592
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable cholesterol binding activity. Predicted to be involved in SREBP signaling pathway. Located in endoplasmic reticulum membrane. Part of protein-containing complex. Is expressed in gonad. Used to study hereditary spastic paraplegia. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 18 and hereditary spastic paraplegia 62. Orthologous to human ERLIN1 (ER lipid raft associated 1) and ERLIN2 (ER lipid raft associated 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See erl-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 6

Sequence:: Chromosome: IV; NC_003282.8 (12287928..12289392)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

C42C1.15 deficiency does not cause an obvious phenotype in C. elegans.
Title: Characterization of the C. elegans erlin homologue.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C42C1.9 (e-PCR)
- UniSTS:306161

STS4-184 (e-PCR)
- UniSTS:242174

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables cholesterol binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
NOT involved_in ERAD pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in SREBP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: Erlin

NP_502339.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

12287928..12289392

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_069938.5 → NP_502339.1 Erlin [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_502339.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A3QMC6

Conserved Domains (1) summary

cd03406
Location:14 → 303

SPFH_like_u3; Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily