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    fhod-1 FH1/FH2 domain-containing protein 3;FH1/FH2 domain-containing protein 3-like;Formin HOmology Domain [ Caenorhabditis elegans ]

    Gene ID: 172133, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fhod-1
    Official Full Name
    FH1/FH2 domain-containing protein 3;FH1/FH2 domain-containing protein 3-like;Formin HOmology Domain
    Primary source
    WormBase:WBGene00016735
    Locus tag
    CELE_C46H11.11
    See related
    AllianceGenome:WB:WBGene00016735
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable actin filament binding activity. Involved in actin filament organization and embryonic body morphogenesis. Located in actin cytoskeleton. Is expressed in several structures, including intestine; muscle cell; pharynx; reproductive system; and seam cell. Human ortholog(s) of this gene implicated in familial hypertrophic cardiomyopathy. Orthologous to human FHOD1 (formin homology 2 domain containing 1) and FHOD3 (formin homology 2 domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See fhod-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    19
    Sequence:
    Chromosome: I; NC_003279.8 (5058251..5068831, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Flavin-containing monooxygenase Neighboring gene F-box C protein;F-box domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene V-type proton ATPase subunit

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. FHOD formin and SRF promote post-embryonic striated muscle growth through separate pathways in C. elegans. Yingling CV, et al. Exp Cell Res, 2021 Jan 1. PMID 33221314, Free PMC Article
    2. INF2- and FHOD-related formins promote ovulation in the somatic gonad of C. elegans. Hegsted A, et al. Cytoskeleton (Hoboken), 2016 Dec. PMID 27770600, Free PMC Article
    3. Loss of Sarcomere-associated Formins Disrupts Z-line Organization, but does not Prevent Thin Filament Assembly in Caenorhabditis elegans Muscle. Mi-Mi L, et al. J Cytol Histol, 2015 Mar. PMID 26161293, Free PMC Article
    4. CYK-1/Formin activation in cortical RhoA signaling centers promotes organismal left-right symmetry breaking. Middelkoop TC, et al. Proc Natl Acad Sci U S A, 2021 May 18. PMID 33972425, Free PMC Article
    5. Tissue-Specific Functions of fem-2/PP2c Phosphatase and fhod-1/formin During Caenorhabditis elegans Embryonic Morphogenesis. Refai O, et al. G3 (Bethesda), 2018 Jul 2. PMID 29720391, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CYK-1/Formin activation in cortical RhoA signaling centers promotes organismal left-right symmetry breaking.
      Title: CYK-1/Formin activation in cortical RhoA signaling centers promotes organismal left-right symmetry breaking.
    2. FHOD formin and SRF promote post-embryonic striated muscle growth through separate pathways in C. elegans.
      Title: FHOD formin and SRF promote post-embryonic striated muscle growth through separate pathways in C. elegans.
    3. EXC-6 plays a role directly in the spermatheca, perhaps by modulating the ability of the spermatheca wall to rapidly accommodate an incoming oocyte, while FHOD-1 may play an indirect role relating to its known importance in the growth and function of the egg-laying muscles
      Title: INF2- and FHOD-related formins promote ovulation in the somatic gonad of C. elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cortical actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in embryonic body morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    FH1/FH2 domain-containing protein 3;FH1/FH2 domain-containing protein 3-like;Formin HOmology Domain
    NP_001300413.1
    • Confirmed by transcript evidence
    NP_001300414.1
    • Confirmed by transcript evidence
    NP_001300415.1
    • Confirmed by transcript evidence
    NP_001300416.1
    • Product from WormBase gene class fhod;
      Confirmed by transcript evidence
    NP_001300417.1
    • Product from WormBase gene class fhod;
      Confirmed by transcript evidence
    NP_001300418.1
    • Product from WormBase gene class fhod;
      Confirmed by transcript evidence
    NP_001300419.1
    • Product from WormBase gene class fhod;
      Confirmed by transcript evidence
    NP_491513.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      5058251..5068831 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001313484.2 → NP_001300413.1  FH1/FH2 domain-containing protein 3 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AR72
      Conserved Domains (1) summary
      cl19758
      Location:669 → 1029
      FH2; Formin Homology 2 Domain

    2. NM_059112.4 → NP_491513.2  FH1/FH2 domain-containing protein 3-like [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491513.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFZ9
      Conserved Domains (1) summary
      cl19758
      Location:827 → 1187
      FH2; Formin Homology 2 Domain

    3. NM_001313486.4 → NP_001300415.1  FH1/FH2 domain-containing protein 3 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AQN9
      Conserved Domains (1) summary
      cl19758
      Location:686 → 1046
      FH2; Formin Homology 2 Domain

    4. NM_001313485.3 → NP_001300414.1  FH1/FH2 domain-containing protein 3-like [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ATM4
      Conserved Domains (1) summary
      cl19758
      Location:844 → 1204
      FH2; Formin Homology 2 Domain

    5. NM_001313488.4 → NP_001300417.1  Formin HOmology Domain [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AWK6
      Conserved Domains (1) summary
      cl19758
      Location:1161 → 1522
      FH2; Formin Homology 2 Domain

    6. NM_001313490.3 → NP_001300419.1  Formin HOmology Domain [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ATM7
      Conserved Domains (1) summary
      cl19758
      Location:1003 → 1364
      FH2; Formin Homology 2 Domain

    7. NM_001313489.3 → NP_001300418.1  Formin HOmology Domain [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AR77
      Conserved Domains (1) summary
      cl19758
      Location:1020 → 1381
      FH2; Formin Homology 2 Domain

    8. NM_001313487.3 → NP_001300416.1  Formin HOmology Domain [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AU72
      Conserved Domains (1) summary
      cl19758
      Location:1178 → 1539
      FH2; Formin Homology 2 Domain
    Nucleotide Protein
    Heading Accession and Version

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