fat-2 Delta(12) fatty acid desaturase fat-2;Fatty acid desaturase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: fat-2
Official Full Name: Delta(12) fatty acid desaturase fat-2;Fatty acid desaturase
Primary source: WormBase:WBGene00001394
Locus tag: CELE_W02A2.1
See related: AllianceGenome:WB:WBGene00001394
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables stearoyl-CoA 9-desaturase activity. Involved in collagen and cuticulin-based cuticle development; fatty acid biosynthetic process; and innate immune response. Predicted to be located in membrane. Is expressed in several structures, including anal depressor muscle; excretory cell; intestine; nervous system; and pharynx. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See fat-2 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 3

Sequence:: Chromosome: IV; NC_003282.8 (13323873..13326395)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Caenorhabditis elegans Delta12-desaturase FAT-2 is a bifunctional desaturase able to desaturate a diverse range of fatty acid substrates at the Delta12 and Delta15 positions
Title: Caenorhabditis elegans Delta12-desaturase FAT-2 is a bifunctional desaturase able to desaturate a diverse range of fatty acid substrates at the Delta12 and Delta15 positions.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

W02A2.1 (e-PCR)
- UniSTS:318926

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables delta12-fatty-acid desaturase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	IEA Inferred from Electronic Annotation more info
enables stearoyl-CoA 9-desaturase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in collagen and cuticulin-based cuticle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in fatty acid elongation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	IEP Inferred from Expression Pattern more info	PubMed
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in reproductive process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in unsaturated fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in unsaturated fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in unsaturated fatty acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Delta(12) fatty acid desaturase fat-2;Fatty acid desaturase

NP_001368476.1

Confirmed by transcript evidence

NP_502560.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

13323873..13326395

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_070159.11 → NP_502560.1 Delta(12) fatty acid desaturase fat-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_502560.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EGA5

Conserved Domains (2) summary

cd03507
Location:39 → 310

Delta12-FADS-like; The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of ...

pfam00487
Location:70 → 323

FA_desaturase; Fatty acid desaturase
NM_001380510.1 → NP_001368476.1 Fatty acid desaturase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A061AJ35

Conserved Domains (1) summary

cl00615
Location:1 → 34

Membrane-FADS-like; The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the ...