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    F44E2.6 Peptide-methionine (R)-S-oxide reductase;putative methionine-R-sulfoxide reductase B [ Caenorhabditis elegans ]

    Gene ID: 176244, updated on 9-Dec-2024

    Summary

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    Official Symbol
    F44E2.6
    Official Full Name
    Peptide-methionine (R)-S-oxide reductase;putative methionine-R-sulfoxide reductase B
    Primary source
    WormBase:WBGene00018419
    Locus tag
    CELE_F44E2.6
    See related
    AllianceGenome:WB:WBGene00018419
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable peptide-methionine (R)-S-oxide reductase activity. Predicted to be involved in protein repair and response to oxidative stress. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 74. Orthologous to several human genes including MSRB2 (methionine sulfoxide reductase B2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See F44E2.6 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    4
    Sequence:
    Chromosome: III; NC_003281.10 (8844494..8845214, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Malectin domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Putative zinc finger protein F44E2.7 Neighboring gene Uncharacterized protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
    2. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide-methionine (R)-S-oxide reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide-methionine (R)-S-oxide reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Peptide-methionine (R)-S-oxide reductase;putative methionine-R-sulfoxide reductase B
    NP_001040853.1
    • Confirmed by transcript evidence
    NP_001360042.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      8844494..8845214 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001372638.3 → NP_001360042.1  putative methionine-R-sulfoxide reductase B [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34436
      Conserved Domains (1) summary
      pfam01641
      Location:29 → 150
      SelR; SelR domain

    2. NM_001047388.3 → NP_001040853.1  Peptide-methionine (R)-S-oxide reductase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040853.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q1W0S5
      Conserved Domains (1) summary
      cl15841
      Location:10 → 145
      SelR; SelR domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34436.1

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