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    Dtx3 deltex 3, E3 ubiquitin ligase [ Mus musculus (house mouse) ]

    Gene ID: 80904, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Dtx3provided by MGI
    Official Full Name
    deltex 3, E3 ubiquitin ligaseprovided by MGI
    Primary source
    MGI:MGI:2135752
    See related
    Ensembl:ENSMUSG00000040415 AllianceGenome:MGI:2135752
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mg310; Deltex3
    Summary
    Predicted to enable ubiquitin protein ligase activity. Acts upstream of or within Notch signaling pathway. Predicted to be located in cytoplasm. Predicted to be active in nucleoplasm. Is expressed in central nervous system and urinary system. Orthologous to human DTX3 (deltex E3 ubiquitin ligase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 162.2), whole brain E14.5 (RPKM 120.6) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dtx3 in Genome Data Viewer
    Location:
    10 D3; 10 74.5 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (127026242..127032367, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (127190373..127196498, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene beta-1,4-N-acetyl-galactosaminyl transferase 1 Neighboring gene solute carrier family 26, member 10 Neighboring gene Rho guanine nucleotide exchange factor 25 Neighboring gene RIKEN cDNA F420014N23 gene Neighboring gene phosphatidylinositol-5-phosphate 4-kinase, type II, gamma Neighboring gene STARR-seq mESC enhancer starr_28215 Neighboring gene kinesin family member 5A Neighboring gene predicted gene, 40800

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis. Kishi N, et al. Int J Dev Neurosci, 2001 Feb. PMID 11226752
    2. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    5. A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Thompson CL, et al. Neuron, 2014 Jul 16. PMID 24952961, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC106339

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within Notch signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within Notch signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    probable E3 ubiquitin-protein ligase DTX3
    Names
    RING-type E3 ubiquitin transferase DTX3
    deltex 3 homolog
    mDTX3
    protein deltex-3
    NP_001355261.1
    NP_109639.1
    XP_006514397.1
    XP_006514399.1
    XP_006514400.1
    XP_030101258.1
    XP_030101259.1
    XP_030101260.1
    XP_030101261.1
    XP_030101262.1
    XP_030101263.1
    XP_030101264.1
    XP_030101265.1
    XP_036012008.1
    XP_036012009.1
    XP_036012010.1
    XP_036012011.1
    XP_036012012.1
    XP_036012013.1
    XP_036012014.1
    XP_036012015.1
    XP_036012016.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368332.1 → NP_001355261.1  probable E3 ubiquitin-protein ligase DTX3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC144852
      Consensus CDS
      CCDS88100.1
      UniProtKB/TrEMBL
      D3YV13, Q3UFK3
      Related
      ENSMUSP00000114776.2, ENSMUST00000130855.8
      Conserved Domains (2) summary
      cd16711
      Location:166 → 206
      RING-HC_DTX3; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Deltex3 (DTX3) and similar proteins
      pfam18102
      Location:213 → 347
      DTC; Deltex C-terminal domain

    2. NM_030714.2 → NP_109639.1  probable E3 ubiquitin-protein ligase DTX3 isoform 1

      See identical proteins and their annotated locations for NP_109639.1

      Status: VALIDATED

      Source sequence(s)
      BC099687
      Consensus CDS
      CCDS36078.1
      UniProtKB/Swiss-Prot
      Q4FZD3, Q80V91, Q9ER06
      UniProtKB/TrEMBL
      Q3UFK3
      Related
      ENSMUSP00000044627.8, ENSMUST00000038217.14
      Conserved Domains (2) summary
      cd16711
      Location:163 → 203
      RING-HC_DTX3; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Deltex3 (DTX3) and similar proteins
      pfam18102
      Location:210 → 344
      DTC; Deltex C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      127026242..127032367 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245400.1 → XP_030101260.1  probable E3 ubiquitin-protein ligase DTX3 isoform X2

      UniProtKB/TrEMBL
      E9Q3J1, Q3UFK3
      Conserved Domains (2) summary
      cd16711
      Location:163 → 203
      RING-HC_DTX3; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Deltex3 (DTX3) and similar proteins
      pfam18102
      Location:210 → 322
      DTC; Deltex C-terminal domain

    2. XM_030245402.2 → XP_030101262.1  probable E3 ubiquitin-protein ligase DTX3 isoform X4

      UniProtKB/Swiss-Prot
      Q4FZD3, Q80V91, Q9ER06
      UniProtKB/TrEMBL
      Q3UFK3
      Conserved Domains (2) summary
      cd16711
      Location:163 → 203
      RING-HC_DTX3; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Deltex3 (DTX3) and similar proteins
      pfam18102
      Location:210 → 344
      DTC; Deltex C-terminal domain

    3. XM_030245401.2 → XP_030101261.1  probable E3 ubiquitin-protein ligase DTX3 isoform X3

      UniProtKB/TrEMBL
      D3YV13, Q3UFK3
      Conserved Domains (2) summary
      cd16711
      Location:166 → 206
      RING-HC_DTX3; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Deltex3 (DTX3) and similar proteins
      pfam18102
      Location:213 → 347
      DTC; Deltex C-terminal domain

    4. XM_036156118.1 → XP_036012011.1  probable E3 ubiquitin-protein ligase DTX3 isoform X2

      UniProtKB/TrEMBL
      E9Q3J1, Q3UFK3
      Conserved Domains (2) summary
      cd16711
      Location:163 → 203
      RING-HC_DTX3; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Deltex3 (DTX3) and similar proteins
      pfam18102
      Location:210 → 322
      DTC; Deltex C-terminal domain

    5. XM_036156116.1 → XP_036012009.1  probable E3 ubiquitin-protein ligase DTX3 isoform X2

      UniProtKB/TrEMBL
      E9Q3J1, Q3UFK3
      Conserved Domains (2) summary
      cd16711
      Location:163 → 203
      RING-HC_DTX3; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Deltex3 (DTX3) and similar proteins
      pfam18102
      Location:210 → 322
      DTC; Deltex C-terminal domain

    6. XM_030245403.2 → XP_030101263.1  probable E3 ubiquitin-protein ligase DTX3 isoform X4

      UniProtKB/Swiss-Prot
      Q4FZD3, Q80V91, Q9ER06
      UniProtKB/TrEMBL
      Q3UFK3
      Conserved Domains (2) summary
      cd16711
      Location:163 → 203
      RING-HC_DTX3; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Deltex3 (DTX3) and similar proteins
      pfam18102
      Location:210 → 344
      DTC; Deltex C-terminal domain

    7. XM_036156123.1 → XP_036012016.1  probable E3 ubiquitin-protein ligase DTX3 isoform X4

      UniProtKB/Swiss-Prot
      Q4FZD3, Q80V91, Q9ER06
      UniProtKB/TrEMBL
      Q3UFK3
      Conserved Domains (2) summary
      cd16711
      Location:163 → 203
      RING-HC_DTX3; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Deltex3 (DTX3) and similar proteins
      pfam18102
      Location:210 → 344
      DTC; Deltex C-terminal domain

    8. XM_036156120.1 → XP_036012013.1  probable E3 ubiquitin-protein ligase DTX3 isoform X4

      UniProtKB/Swiss-Prot
      Q4FZD3, Q80V91, Q9ER06
      UniProtKB/TrEMBL
      Q3UFK3
      Conserved Domains (2) summary
      cd16711
      Location:163 → 203
      RING-HC_DTX3; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Deltex3 (DTX3) and similar proteins
      pfam18102
      Location:210 → 344
      DTC; Deltex C-terminal domain

    9. XM_036156122.1 → XP_036012015.1  probable E3 ubiquitin-protein ligase DTX3 isoform X4

      UniProtKB/Swiss-Prot
      Q4FZD3, Q80V91, Q9ER06
      UniProtKB/TrEMBL
      Q3UFK3
      Conserved Domains (2) summary
      cd16711
      Location:163 → 203
      RING-HC_DTX3; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Deltex3 (DTX3) and similar proteins
      pfam18102
      Location:210 → 344
      DTC; Deltex C-terminal domain

    10. XM_006514334.2 → XP_006514397.1  probable E3 ubiquitin-protein ligase DTX3 isoform X1

      See identical proteins and their annotated locations for XP_006514397.1

      UniProtKB/TrEMBL
      Q3UFK3
      Conserved Domains (2) summary
      cd16711
      Location:166 → 206
      RING-HC_DTX3; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Deltex3 (DTX3) and similar proteins
      pfam18102
      Location:213 → 325
      DTC; Deltex C-terminal domain

    11. XM_006514337.4 → XP_006514400.1  probable E3 ubiquitin-protein ligase DTX3 isoform X2

      UniProtKB/TrEMBL
      E9Q3J1, Q3UFK3
      Related
      ENSMUSP00000111937.2, ENSMUST00000116229.2
      Conserved Domains (2) summary
      cd16711
      Location:163 → 203
      RING-HC_DTX3; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Deltex3 (DTX3) and similar proteins
      pfam18102
      Location:210 → 322
      DTC; Deltex C-terminal domain

    12. XM_036156121.1 → XP_036012014.1  probable E3 ubiquitin-protein ligase DTX3 isoform X4

      UniProtKB/Swiss-Prot
      Q4FZD3, Q80V91, Q9ER06
      UniProtKB/TrEMBL
      Q3UFK3
      Conserved Domains (2) summary
      cd16711
      Location:163 → 203
      RING-HC_DTX3; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Deltex3 (DTX3) and similar proteins
      pfam18102
      Location:210 → 344
      DTC; Deltex C-terminal domain

    13. XM_036156117.1 → XP_036012010.1  probable E3 ubiquitin-protein ligase DTX3 isoform X2

      UniProtKB/TrEMBL
      E9Q3J1, Q3UFK3
      Conserved Domains (2) summary
      cd16711
      Location:163 → 203
      RING-HC_DTX3; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Deltex3 (DTX3) and similar proteins
      pfam18102
      Location:210 → 322
      DTC; Deltex C-terminal domain

    14. XM_036156119.1 → XP_036012012.1  probable E3 ubiquitin-protein ligase DTX3 isoform X3

      UniProtKB/TrEMBL
      D3YV13, Q3UFK3
      Conserved Domains (2) summary
      cd16711
      Location:166 → 206
      RING-HC_DTX3; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Deltex3 (DTX3) and similar proteins
      pfam18102
      Location:213 → 347
      DTC; Deltex C-terminal domain

    15. XM_036156115.1 → XP_036012008.1  probable E3 ubiquitin-protein ligase DTX3 isoform X1

      UniProtKB/TrEMBL
      Q3UFK3
      Conserved Domains (2) summary
      cd16711
      Location:166 → 206
      RING-HC_DTX3; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Deltex3 (DTX3) and similar proteins
      pfam18102
      Location:213 → 325
      DTC; Deltex C-terminal domain

    16. XM_030245405.1 → XP_030101265.1  probable E3 ubiquitin-protein ligase DTX3 isoform X4

      UniProtKB/Swiss-Prot
      Q4FZD3, Q80V91, Q9ER06
      UniProtKB/TrEMBL
      Q3UFK3
      Conserved Domains (2) summary
      cd16711
      Location:163 → 203
      RING-HC_DTX3; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Deltex3 (DTX3) and similar proteins
      pfam18102
      Location:210 → 344
      DTC; Deltex C-terminal domain

    17. XM_030245399.2 → XP_030101259.1  probable E3 ubiquitin-protein ligase DTX3 isoform X2

      UniProtKB/TrEMBL
      E9Q3J1, Q3UFK3
      Conserved Domains (2) summary
      cd16711
      Location:163 → 203
      RING-HC_DTX3; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Deltex3 (DTX3) and similar proteins
      pfam18102
      Location:210 → 322
      DTC; Deltex C-terminal domain

    18. XM_030245404.2 → XP_030101264.1  probable E3 ubiquitin-protein ligase DTX3 isoform X4

      UniProtKB/Swiss-Prot
      Q4FZD3, Q80V91, Q9ER06
      UniProtKB/TrEMBL
      Q3UFK3
      Conserved Domains (2) summary
      cd16711
      Location:163 → 203
      RING-HC_DTX3; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Deltex3 (DTX3) and similar proteins
      pfam18102
      Location:210 → 344
      DTC; Deltex C-terminal domain

    19. XM_006514336.4 → XP_006514399.1  probable E3 ubiquitin-protein ligase DTX3 isoform X1

      See identical proteins and their annotated locations for XP_006514399.1

      UniProtKB/TrEMBL
      Q3UFK3
      Conserved Domains (2) summary
      cd16711
      Location:166 → 206
      RING-HC_DTX3; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Deltex3 (DTX3) and similar proteins
      pfam18102
      Location:213 → 325
      DTC; Deltex C-terminal domain

    20. XM_030245398.2 → XP_030101258.1  probable E3 ubiquitin-protein ligase DTX3 isoform X2

      UniProtKB/TrEMBL
      E9Q3J1, Q3UFK3
      Conserved Domains (2) summary
      cd16711
      Location:163 → 203
      RING-HC_DTX3; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Deltex3 (DTX3) and similar proteins
      pfam18102
      Location:210 → 322
      DTC; Deltex C-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80V91.2 GenPept UniProtKB/Swiss-Prot:Q80V91

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