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    Sars2 seryl-aminoacyl-tRNA synthetase 2 [ Mus musculus (house mouse) ]

    Gene ID: 71984, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Sars2provided by MGI
    Official Full Name
    seryl-aminoacyl-tRNA synthetase 2provided by MGI
    Primary source
    MGI:MGI:1919234
    See related
    Ensembl:ENSMUSG00000070699 AllianceGenome:MGI:1919234
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SerRS; SerRSmt; D7Ertd353e; 2410015F05Rik
    Summary
    Predicted to enable ATP binding activity; serine-tRNA ligase activity; and tRNA binding activity. Predicted to be involved in mitochondrial seryl-tRNA aminoacylation. Located in mitochondrion. Is expressed in several structures, including alimentary system; eye; integumental system; nervous system; and respiratory system. Orthologous to human SARS2 (seryl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in thymus adult (RPKM 17.6), adrenal adult (RPKM 16.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sars2 in Genome Data Viewer
    Location:
    7 B1; 7 16.91 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (28441393..28453304)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (28741957..28753879)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene F-box protein 17 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:29526699-29526882 Neighboring gene mitochondrial ribosomal protein S12 Neighboring gene coiled-coil glutamate-rich protein 2 Neighboring gene nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta Neighboring gene STARR-positive B cell enhancer ABC_E128 Neighboring gene sirtuin 2 Neighboring gene predicted gene, 19897 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:29565175-29565376 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:29565964-29566190

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The bidirectional promoter of two genes for the mitochondrial translational apparatus in mouse is regulated by an array of CCAAT boxes interacting with the transcription factor NF-Y. Zanotto E, et al. Nucleic Acids Res, 2007. PMID 17179180, Free PMC Article
    2. Genomic organization, expression, and subcellular localization of mouse mitochondrial seryl-tRNA synthetase. Gibbons WJ Jr, et al. Biochem Biophys Res Commun, 2004 May 7. PMID 15081407
    3. Characterization and tRNA recognition of mammalian mitochondrial seryl-tRNA synthetase. Yokogawa T, et al. J Biol Chem, 2000 Jun 30. PMID 10764807
    4. In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype. Gineste C, et al. Neuromuscul Disord, 2013 Apr. PMID 23375831
    5. Mitochondrial protein interactome elucidated by chemical cross-linking mass spectrometry. Schweppe DK, et al. Proc Natl Acad Sci U S A, 2017 Feb 14. PMID 28130547, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of an array of 4 CCAAT box elements required for efficient transcription of the Sars2 gene.
      Title: The bidirectional promoter of two genes for the mitochondrial translational apparatus in mouse is regulated by an array of CCAAT boxes interacting with the transcription factor NF-Y.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables serine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-tRNA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial seryl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in seryl-tRNA aminoacylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine--tRNA ligase, mitochondrial
    Names
    seryl-tRNA synthetase, mitochondrial
    seryl-tRNA(Ser/Sec) synthetase
    NP_076126.2
    XP_006540438.1
    XP_006540439.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023637.3 → NP_076126.2  serine--tRNA ligase, mitochondrial precursor

      Status: VALIDATED

      Source sequence(s)
      AK010491, BY649585, CX122368
      Consensus CDS
      CCDS21053.1
      UniProtKB/Swiss-Prot
      Q68FL2, Q9CWP1, Q9JJL8
      Related
      ENSMUSP00000092216.5, ENSMUST00000094632.6
      Conserved Domains (3) summary
      PRK05431
      Location:67 → 493
      PRK05431; seryl-tRNA synthetase; Provisional
      cd00770
      Location:185 → 485
      SerRS_core; Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound ...
      cl12057
      Location:67 → 172
      Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      28441393..28453304
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540375.5 → XP_006540438.1  serine--tRNA ligase, mitochondrial isoform X1

      Conserved Domains (1) summary
      PRK05431
      Location:67 → 253
      PRK05431; seryl-tRNA synthetase; Provisional

    2. XM_006540376.3 → XP_006540439.1  serine--tRNA ligase, mitochondrial isoform X2

      Conserved Domains (1) summary
      cl00268
      Location:1 → 228
      class_II_aaRS-like_core; Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches ...

    RNA

    1. XR_003946566.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JJL8.2 GenPept UniProtKB/Swiss-Prot:Q9JJL8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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