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    Dap3 death associated protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 65111, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dap3provided by MGI
    Official Full Name
    death associated protein 3provided by MGI
    Primary source
    MGI:MGI:1929538
    See related
    Ensembl:ENSMUSG00000068921 AllianceGenome:MGI:1929538
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DAP-3; S29mt; MRP-S29; 4921514D13Rik
    Summary
    Predicted to be a structural constituent of ribosome. Acts upstream of or within apoptotic mitochondrial changes. Located in mitochondrial matrix. Is expressed in several structures, including alimentary system; central nervous system; gonad; hemolymphoid system gland; and sensory organ. Orthologous to human DAP3 (death associated protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 20.1), placenta adult (RPKM 12.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dap3 in Genome Data Viewer
    Location:
    3 F1; 3 39.01 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (88828110..88858504, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (88920803..88951213, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene gon-4 like Neighboring gene nuclear encoded rRNA 5S 197 Neighboring gene misato 1, mitochondrial distribution and morphology regulator Neighboring gene ASH1 like histone lysine methyltransferase Neighboring gene STARR-seq mESC enhancer starr_08222 Neighboring gene predicted gene, 26465 Neighboring gene predicted gene, 24403

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Death-associated protein 3 regulates cellular senescence through oxidative stress response. Murata Y, et al. FEBS Lett, 2006 Nov 13. PMID 17056041
    2. Critical function of death-associated protein 3 in T cell receptor-mediated apoptosis induction. Tosa N, et al. Biochem Biophys Res Commun, 2010 May 7. PMID 20381457
    3. Death-associated protein 3 localizes to the mitochondria and is involved in the process of mitochondrial fragmentation during cell death. Mukamel Z, et al. J Biol Chem, 2004 Aug 27. PMID 15175341
    4. Mammalian dap3 is an essential gene required for mitochondrial homeostasis in vivo and contributing to the extrinsic pathway for apoptosis. Kim HR, et al. FASEB J, 2007 Jan. PMID 17135360
    5. Death-associated Protein 3 Regulates Mitochondrial-encoded Protein Synthesis and Mitochondrial Dynamics. Xiao L, et al. J Biol Chem, 2015 Oct 9. PMID 26306039, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DAP3 plays important roles in mitochondrial function and dynamics
      Title: Death-associated Protein 3 Regulates Mitochondrial-encoded Protein Synthesis and Mitochondrial Dynamics.
    2. DAP3 is critical for TCR-mediated induction of apoptosis at the downstream of Nur77.
      Title: Critical function of death-associated protein 3 in T cell receptor-mediated apoptosis induction.
    3. requirement for DAP3 in mitochondrial respiration was also revealed by oxygen consumption measurements using cultured cells treated with DAP3-specific small interfering RNA
      Title: Mammalian dap3 is an essential gene required for mitochondrial homeostasis in vivo and contributing to the extrinsic pathway for apoptosis.
    4. DAP3 has a role in the molecular pathway that culminates in fragmented mitochondria
      Title: Death-associated protein 3 localizes to the mitochondria and is involved in the process of mitochondrial fragmentation during cell death.
    5. DAP3 is reduced in both replicative and premature senescence induced by oxidative stress, and the DAP3 reduction induced by oxidative stress is observed mostly in a mitochondrial fraction.
      Title: Death-associated protein 3 regulates cellular senescence through oxidative stress response.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic mitochondrial changes IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitochondrial translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mitochondrial small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial small ribosomal subunit ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of mitochondrial small ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    small ribosomal subunit protein mS29
    Names
    28S ribosomal protein S29, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164533.1 → NP_001158005.1  small ribosomal subunit protein mS29 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC127377, AK014280, AV340314, CD741520
      Consensus CDS
      CCDS50955.1
      UniProtKB/TrEMBL
      A0A0R4J1B9
      Related
      ENSMUSP00000103115.5, ENSMUST00000107491.11
      Conserved Domains (1) summary
      pfam10236
      Location:97 → 362
      DAP3; Mitochondrial ribosomal death-associated protein 3

    2. NM_001368419.1 → NP_001355348.1  small ribosomal subunit protein mS29 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC127377
      Consensus CDS
      CCDS89651.1
      UniProtKB/Swiss-Prot
      Q8C2B2, Q8CCQ8, Q8VCK8, Q9CRT4, Q9CS11, Q9D5V9, Q9ER88
      Conserved Domains (1) summary
      pfam10236
      Location:92 → 387
      DAP3; Mitochondrial ribosomal death-associated protein 3

    3. NM_022994.3 → NP_075370.2  small ribosomal subunit protein mS29 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
      Source sequence(s)
      AC127377, AJ250375, AV340314
      Consensus CDS
      CCDS17486.2
      UniProtKB/TrEMBL
      G3X9M0
      Related
      ENSMUSP00000088456.5, ENSMUST00000090938.11
      Conserved Domains (1) summary
      pfam10236
      Location:97 → 392
      DAP3; Mitochondrial ribosomal death-associated protein 3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      88828110..88858504 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501863.5 → XP_006501926.1  small ribosomal subunit protein mS29 isoform X1

      UniProtKB/Swiss-Prot
      Q8C2B2, Q8CCQ8, Q8VCK8, Q9CRT4, Q9CS11, Q9D5V9, Q9ER88
      Conserved Domains (1) summary
      pfam10236
      Location:92 → 387
      DAP3; Mitochondrial ribosomal death-associated protein 3

    2. XM_006501864.3 → XP_006501927.1  small ribosomal subunit protein mS29 isoform X1

      UniProtKB/Swiss-Prot
      Q8C2B2, Q8CCQ8, Q8VCK8, Q9CRT4, Q9CS11, Q9D5V9, Q9ER88
      Related
      ENSMUSP00000134422.2, ENSMUST00000173135.8
      Conserved Domains (1) summary
      pfam10236
      Location:92 → 387
      DAP3; Mitochondrial ribosomal death-associated protein 3

    3. XM_006501869.5 → XP_006501932.1  small ribosomal subunit protein mS29 isoform X1

      UniProtKB/Swiss-Prot
      Q8C2B2, Q8CCQ8, Q8VCK8, Q9CRT4, Q9CS11, Q9D5V9, Q9ER88
      Conserved Domains (1) summary
      pfam10236
      Location:92 → 387
      DAP3; Mitochondrial ribosomal death-associated protein 3

    4. XM_006501865.4 → XP_006501928.1  small ribosomal subunit protein mS29 isoform X3

      Conserved Domains (1) summary
      pfam10236
      Location:97 → 339
      DAP3; Mitochondrial ribosomal death-associated protein 3

    5. XM_030252745.1 → XP_030108605.1  small ribosomal subunit protein mS29 isoform X2

      Conserved Domains (1) summary
      pfam10236
      Location:92 → 357
      DAP3; Mitochondrial ribosomal death-associated protein 3

    6. XM_036163214.1 → XP_036019107.1  small ribosomal subunit protein mS29 isoform X8

      Conserved Domains (1) summary
      pfam10236
      Location:92 → 304
      DAP3; Mitochondrial ribosomal death-associated protein 3

    7. XM_006501868.5 → XP_006501931.1  small ribosomal subunit protein mS29 isoform X9

      Conserved Domains (1) summary
      pfam10236
      Location:97 → 282
      DAP3; Mitochondrial ribosomal death-associated protein 3

    8. XM_006501866.5 → XP_006501929.1  small ribosomal subunit protein mS29 isoform X6

      Conserved Domains (1) summary
      pfam10236
      Location:97 → 312
      DAP3; Mitochondrial ribosomal death-associated protein 3

    9. XM_030252747.1 → XP_030108607.1  small ribosomal subunit protein mS29 isoform X7

      Conserved Domains (1) summary
      pfam10236
      Location:92 → 307
      DAP3; Mitochondrial ribosomal death-associated protein 3

    10. XM_036163212.1 → XP_036019105.1  small ribosomal subunit protein mS29 isoform X4

      Conserved Domains (1) summary
      pfam10236
      Location:92 → 334
      DAP3; Mitochondrial ribosomal death-associated protein 3

    11. XM_006501867.4 → XP_006501930.1  small ribosomal subunit protein mS29 isoform X5

      Conserved Domains (1) summary
      pfam10236
      Location:97 → 309
      DAP3; Mitochondrial ribosomal death-associated protein 3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ER88.1 GenPept UniProtKB/Swiss-Prot:Q9ER88

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