SULT1B1 sulfotransferase family 1B member 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SULT1B1provided by HGNC
Official Full Name: sulfotransferase family 1B member 1provided by HGNC
Primary source: HGNC:HGNC:17845
See related: Ensembl:ENSG00000173597 MIM:608436; AllianceGenome:HGNC:17845
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ST1B1; ST1B2; SULT1B2
Summary: Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. However, the total genomic length of this gene is greater than that of other SULT1 genes. [provided by RefSeq, Jul 2008]
Expression: Biased expression in duodenum (RPKM 43.3), small intestine (RPKM 41.2) and 5 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 4q13.3

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (69721167..69760620, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (73055983..73095434, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (70586885..70626338, complement)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

(L145V) selectively expressed in African descendants exhibits altered kinetic properties
Title: A high frequency missense SULT1B1 allelic variant (L145V) selectively expressed in African descendants exhibits altered kinetic properties.
the intersubunit interactions of SULT1B1 as it relates to enzyme activity
Title: An engineered heterodimeric model to investigate SULT1B1 dependence on intersubunit communication.
Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.
linkage to SULT1E1 and a SULT1D1 pseudogene on chromosome 4
Title: Structure and localization of the human SULT1B1 gene: neighborhood to SULT1E1 and a SULT1D pseudogene.
crystal structures of two members of SULT1 family, SULT1B1 and SULT1C1, both in complex with the product of the PAPS cofactor, adenosine-3-5-diphosphate (PAP).
Title: Crystal structures of human sulfotransferases SULT1B1 and SULT1C1 complexed with the cofactor product adenosine-3'- 5'-diphosphate (PAP).

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables aryl sulfotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aryl sulfotransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sulfotransferase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in 3'-phosphoadenosine 5'-phosphosulfate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in biogenic amine metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in epithelial cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in ethanol catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in flavonoid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phenol-containing compound metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in sulfation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sulfation	IDA Inferred from Direct Assay more info	PubMed
involved_in sulfation	IDA Inferred from Direct Assay more info	PubMed
involved_in thyroid hormone metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in xenobiotic metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	NAS Non-traceable Author Statement more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info

General protein information

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Preferred Names: sulfotransferase 1B1

Names: sulfotransferase 1B2; sulfotransferase family, cytosolic, 1B, member 1; thyroid hormone sulfotransferase

NP_055280.2

EC 2.8.2.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.