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    CG32075 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 326192, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG32075provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0052075
    Locus tag
    Dmel_CG32075
    See related
    AllianceGenome:FB:FBgn0052075
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6316; Dmel\CG32075
    Summary
    Predicted to enable endonuclease activity. Predicted to be involved in maturation of 5.8S rRNA and maturation of LSU-rRNA. Predicted to be part of Las1 complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Wilson-Turner syndrome. Orthologous to human LAS1L (LAS1 like ribosome biogenesis factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG32075 in Genome Data Viewer
    Location:
    68A3-68A4; 3-34 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11062726..11064941, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11055826..11058041, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Biogenesis of lysosome-related organelles complex 1, subunit 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Suppressor of Under-Replication Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Influence of the SuUR gene on intercalary heterochromatin in Drosophila melanogaster polytene chromosomes. Zhimulev IF, et al. Chromosoma, 2003 Mar. PMID 12644953
    2. Transcripts immunoprecipitated with Sxl protein in primordial germ cells of Drosophila embryos. Ota R, et al. Dev Growth Differ, 2017 Dec. PMID 29124738
    3. The Drosophila suppressor of underreplication protein binds to late-replicating regions of polytene chromosomes. Makunin IV, et al. Genetics, 2002 Mar. PMID 11901119, Free PMC Article
    4. The pentameric nucleoplasmin fold is present in Drosophila FKBP39 and a large number of chromatin-related proteins. Edlich-Muth C, et al. J Mol Biol, 2015 May 22. PMID 25813344, Free PMC Article
    5. Genome-wide analysis of self-renewal in Drosophila neural stem cells by transgenic RNAi. Neumüller RA, et al. Cell Stem Cell, 2011 May 6. PMID 21549331, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in maturation of 5.8S rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of LSU-rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Las1 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG32075-PA
    CG32075-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      11062726..11064941 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140171.4 → NP_648428.1  uncharacterized protein Dmel_CG32075, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648428.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SZY9
      Related
      FBpp0075969
      Conserved Domains (1) summary
      pfam04031
      Location:42 → 186
      Las1; Las1-like

    2. NM_001259783.1 → NP_001246712.1  uncharacterized protein Dmel_CG32075, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246712.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SZY9
      Conserved Domains (1) summary
      pfam04031
      Location:42 → 186
      Las1; Las1-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SZY9 Q8SZY9

    Gene LinkOut

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