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    RpS21 Ribosomal protein S21 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33487, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RpS21provided by FlyBase
    Official Full Name
    Ribosomal protein S21provided by FlyBase
    Primary source
    FLYBASE:FBgn0015521
    Locus tag
    Dmel_CG2986
    See related
    AllianceGenome:FB:FBgn0015521
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2986; Dmel\CG2986; l(2)03575; l(2)168/14; l(2)k16814; M(2)23B; oho23; oho23B; rpS21; S21; S21e
    Summary
    Enables ribosome binding activity. A structural constituent of ribosome. Involved in lymph gland development and regulation of cell population proliferation. Located in cytosolic ribosome. Is expressed in adult heart; imaginal disc; and organism. Orthologous to human RPS21 (ribosomal protein S21). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See RpS21 in Genome Data Viewer
    Location:
    23B5-23B6; 2-7 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2856070..2857029)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2856070..2857029)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Interferon-related developmental regulator 1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Down-regulation of RpS21, a putative translation initiation factor interacting with P40, produces viable minute imagos and larval lethality with overgrown hematopoietic organs and imaginal discs. Török I, et al. Mol Cell Biol, 1999 Mar. PMID 10022917, Free PMC Article
    2. Allele-specific alternative splicing of Drosophila Ribosomal protein S21 suppresses a lethal mutation in the Phosphorylated adaptor for RNA export (Phax) gene. Garcia EL. G3 (Bethesda), 2022 Aug 25. PMID 35920767, Free PMC Article
    3. An RNAi screen for ribosome biogenesis genes required for Drosophila border cell collective migration. Burghardt E, et al. MicroPubl Biol, 2024. PMID 39185014, Free PMC Article
    4. Exploiting codon usage identifies intensity-specific modifiers of Ras/MAPK signaling in vivo. Sawyer JK, et al. PLoS Genet, 2020 Dec. PMID 33296356, Free PMC Article
    5. Opbp is a new architectural/insulator protein required for ribosomal gene expression. Zolotarev N, et al. Nucleic Acids Res, 2017 Dec 1. PMID 29036346, Free PMC Article

    See all (73) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ribosome binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of ribosome HDA PubMed 
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in cytoplasmic translation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lymph gland development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosolic ribosome HDA PubMed 
    located_in cytosolic ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic small ribosomal subunit TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal protein S21
    Names
    CG2986-PA
    CG2986-PB
    CG2986-PD
    CG2986-PE
    CG2986-PF
    Rp S21
    RpS21-PA
    RpS21-PB
    RpS21-PD
    RpS21-PE
    RpS21-PF
    overgrown hematopoietic organs 23B
    overgrown hematopoietic organs at 23B
    overgrown hematopoietic organs-23

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      2856070..2857029
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078738.5 → NP_523462.2  ribosomal protein S21, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523462.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E4NKJ9
      Conserved Domains (1) summary
      pfam01249
      Location:1 → 77
      Ribosomal_S21e; Ribosomal protein S21e

    2. NM_001273041.1 → NP_001259970.1  ribosomal protein S21, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259970.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V027, O76927
      UniProtKB/TrEMBL
      E4NKJ9, M9PEA6
      Conserved Domains (1) summary
      pfam01249
      Location:1 → 79
      Ribosomal_S21e; Ribosomal protein S21e

    3. NM_164507.4 → NP_722854.1  ribosomal protein S21, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722854.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V027, O76927
      UniProtKB/TrEMBL
      E4NKJ9, M9PEA6
      Related
      FBpp0077309
      Conserved Domains (1) summary
      pfam01249
      Location:1 → 79
      Ribosomal_S21e; Ribosomal protein S21e

    4. NM_164508.3 → NP_722855.1  ribosomal protein S21, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722855.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V027, O76927
      UniProtKB/TrEMBL
      E4NKJ9, M9PEA6
      Related
      FBpp0077308
      Conserved Domains (1) summary
      pfam01249
      Location:1 → 79
      Ribosomal_S21e; Ribosomal protein S21e

    5. NM_164506.4 → NP_722853.1  ribosomal protein S21, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722853.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V027, O76927
      UniProtKB/TrEMBL
      E4NKJ9, M9PEA6
      Related
      FBpp0077307
      Conserved Domains (1) summary
      pfam01249
      Location:1 → 79
      Ribosomal_S21e; Ribosomal protein S21e
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PEA6 M9PEA6
    O76927.1 O76927

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