Cul4 Cullin 4 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Cul4provided by FlyBase
Official Full Name: Cullin 4provided by FlyBase
Primary source: FLYBASE:FBgn0033260
Locus tag: Dmel_CG8711
See related: AllianceGenome:FB:FBgn0033260
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG8711; CRL4; cul-4; Cul-4; cul4; CUL4; Cullin4; dCul4; DMcul-4; Dmel\CG8711
Summary: Enables ubiquitin ligase complex scaffold activity. Involved in several processes, including chaeta morphogenesis; eggshell chorion gene amplification; and regulation of signal transduction. Located in nucleus. Part of Cul4-RING E3 ubiquitin ligase complex. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Cabezas type. Orthologous to several human genes including CUL4A (cullin 4A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 44A4-44A4; 2-58 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (8102260..8106318, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (3989765..3993823, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

An E3 ubiquitin ligase, cullin-4 regulates retinal differentiation in Drosophila eye.
Title: An E3 ubiquitin ligase, cullin-4 regulates retinal differentiation in Drosophila eye.
DCAF12 and Cul4 are critical for normal synaptic function and plasticity at larval neuromuscular junctions.
Title: Cul4 ubiquitin ligase cofactor DCAF12 promotes neurotransmitter release and homeostatic plasticity.
These studies provide insights into a novel role of cul-4 in promoting cell survival in the developing Drosophila eye.
Title: Cullin-4 regulates Wingless and JNK signaling-mediated cell death in the Drosophila eye.
BRWD3 functions as a Damage-specific DNA binding protein 1 (DDB1)- and CULLIN (CUL)4-associated factor in a Cullin4-RING Finger E3 Ligase (CRL4) that mediates light-dependent binding of dCRY to CUL4-ROC1-DDB1-BRWD3, inducing ubiquitylation of dCRY
Title: Ramshackle (Brwd3) promotes light-induced ubiquitylation of Drosophila Cryptochrome by DDB1-CUL4-ROC1 E3 ligase complex.
we could not detect Dup hyperaccumulation using mutations in the CRL4(Cdt2) components Cul4 and Ddb1, likely because these cause pleiotropic effects that block cell proliferation
Title: Cell type-dependent requirement for PIP box-regulated Cdt1 destruction during S phase.
Plays a conserved role in the regulation of beta-catenin levels.
Title: Cullin4B/E3-ubiquitin ligase negatively regulates beta-catenin.
loss of CUL4 in Drosophila cells causes G(1) cell cycle arrest and an increased protein level of the CDK inhibitor Dacapo
Title: Involvement of CUL4 ubiquitin E3 ligases in regulating CDK inhibitors Dacapo/p27Kip1 and cyclin E degradation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ubiquitin ligase complex scaffold activity	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IBA Inferred from Biological aspect of Ancestor more info
involved_in chaeta morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in eggshell chorion gene amplification	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of hippo signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in protein polyubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IC Inferred by Curator more info	PubMed
involved_in protein ubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
part_of Cul4-RING E3 ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Cul4-RING E3 ubiquitin ligase complex	IDA Inferred from Direct Assay more info	PubMed
part_of cullin-RING ubiquitin ligase complex	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cullin 4

Names: CG8711-PA; CG8711-PB; Cul4-PA; Cul4-PB; Cullin-4; Cullin4; cul-4; dCullin4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

8102260..8106318 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_136508.4 → NP_610352.2 cullin 4, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_610352.2

Status: REVIEWED

UniProtKB/TrEMBL

Q5BI50

Related

FBpp0087897

Conserved Domains (3) summary

smart00182
Location:503 → 644

CULLIN; Cullin

smart00884
Location:750 → 815

Cullin_Nedd8; Cullin protein neddylation domain

pfam00888
Location:124 → 721

Cullin; Cullin family
NM_001169613.1 → NP_001163084.1 cullin 4, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163084.1

Status: REVIEWED

UniProtKB/TrEMBL

Q5BI50

Conserved Domains (3) summary

smart00182
Location:503 → 644

CULLIN; Cullin

smart00884
Location:750 → 815

Cullin_Nedd8; Cullin protein neddylation domain

pfam00888
Location:124 → 721

Cullin; Cullin family