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    RhoGAP102A Rho GTPase activating protein at 102A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43781, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RhoGAP102Aprovided by FlyBase
    Official Full Name
    Rho GTPase activating protein at 102Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0259216
    Locus tag
    Dmel_CG42316
    See related
    AllianceGenome:FB:FBgn0259216
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BP1050; CG1748; CG34013; CG42316; Dmel\CG42316; Dm_4:1183; mlncRNA102B1; rhoGAP102A
    Old locus tag
    Dmel_CG1748; Dmel_CG34013
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in signal transduction. Orthologous to human ARHGAP36 (Rho GTPase activating protein 36) and ARHGAP6 (Rho GTPase activating protein 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See RhoGAP102A in Genome Data Viewer
    Location:
    102B1-102B1; 4-0 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (254997..265574)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (275623..286200)

    Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene defective proboscis extension response 7 Neighboring gene Nuclear factor I Neighboring gene long non-coding RNA:CR44023

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Accelerated homologous recombination and subsequent genome modification in Drosophila. Baena-Lopez LA, et al. Development, 2013 Dec. PMID 24154526, Free PMC Article
    2. The KRÜPPEL-like transcription factor DATILÓGRAFO is required in specific cholinergic neurons for sexual receptivity in Drosophila females. Schinaman JM, et al. PLoS Biol, 2014 Oct. PMID 25291190, Free PMC Article
    3. Effect of spaceflight on the circadian rhythm, lifespan and gene expression of Drosophila melanogaster. Ma L, et al. PLoS One, 2015. PMID 25798821, Free PMC Article
    4. Molecular mapping of deletion breakpoints on chromosome 4 of Drosophila melanogaster. Podemski L, et al. Chromosoma, 2004 Jun. PMID 15185094
    5. Regulating axon branch stability: the role of p190 RhoGAP in repressing a retraction signaling pathway. Billuart P, et al. Cell, 2001 Oct 19. PMID 11672527

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    mobile_element

    • Loc: 259771-259838 mobile_element_type = transposon:INE-1{}5318
    • Loc: 260948-261036 mobile_element_type = transposon:INE-1{}5319

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTPase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    Rho GTPase activating protein at 102A
    Names
    CG42316-PC
    CG42316-PD
    CG42316-PE
    CG42316-PF
    RhoGAP102A-PC
    RhoGAP102A-PD
    RhoGAP102A-PE
    RhoGAP102A-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004353.4 Reference assembly

      Range
      254997..265574
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258487.3 → NP_001245416.1  Rho GTPase activating protein at 102A, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245416.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H9XVN1
      Conserved Domains (1) summary
      cl02570
      Location:874 → 1069
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

    2. NM_001272121.2 → NP_001259050.1  Rho GTPase activating protein at 102A, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259050.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      L0MPN2
      Conserved Domains (1) summary
      cl02570
      Location:874 → 1069
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

    3. NM_143657.5 → NP_651914.3  Rho GTPase activating protein at 102A, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651914.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V4C2
      Conserved Domains (1) summary
      cl02570
      Location:874 → 1054
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

    4. NM_001038713.4 → NP_001033802.2  Rho GTPase activating protein at 102A, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001033802.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2PDM2
      Conserved Domains (1) summary
      cl02570
      Location:874 → 1064
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    H9XVN1 H9XVN1
    L0MPN2 L0MPN2
    Q2PDM2 Q2PDM2
    Q9V4C2 Q9V4C2

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