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    Kmn1 kinetochore Mis12-Ndc80 network component 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32102, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Kmn1provided by FlyBase
    Official Full Name
    kinetochore Mis12-Ndc80 network component 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0027259
    Locus tag
    Dmel_CG1558
    See related
    AllianceGenome:FB:FBgn0027259
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO03040301.201; CG1558; CT4038; Dmel\CG1558; dmNsl1R; l(1)G0237; nsl1; Nsl1
    Summary
    Involved in mitotic chromosome movement towards spindle pole; mitotic metaphase chromosome alignment; and regulation of cell cycle. Located in kinetochore. Part of MIS12/MIND type complex and Ndc80 complex. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Kmn1 in Genome Data Viewer
    Location:
    10C6-10C7; 1-35 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11571383..11572442, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11465416..11466475, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene RNA polymerase II subunit A Neighboring gene antisense RNA:CR44266 Neighboring gene uncharacterized protein Neighboring gene Receptor accessory protein like 1 Neighboring gene uncharacterized protein Neighboring gene enhancer of yellow 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tumor suppressor roles of CENP-E and Nsl1 in Drosophila epithelial tissues. Clemente-Ruiz M, et al. Cell Cycle, 2014. PMID 24626182, Free PMC Article
    2. A transposable element insertion confers xenobiotic resistance in Drosophila. Mateo L, et al. PLoS Genet, 2014 Aug. PMID 25122208, Free PMC Article
    3. Network of protein interactions within the Drosophila inner kinetochore. Richter MM, et al. Open Biol, 2016 Feb. PMID 26911623, Free PMC Article
    4. Insights from the reconstitution of the divergent outer kinetochore of Drosophila melanogaster. Liu Y, et al. Open Biol, 2016 Feb. PMID 26911624, Free PMC Article
    5. Drosophila Mis12 complex acts as a single functional unit essential for anaphase chromosome movement and a robust spindle assembly checkpoint. Venkei Z, et al. Genetics, 2011 Jan. PMID 20980244, Free PMC Article

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic chromosome movement towards spindle pole IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic metaphase chromosome alignment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MIS12/MIND type complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Ndc80 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    kinetochore Mis12-Ndc80 network component 1
    Names
    CG1558-PA
    CG1558-PB
    Kmn1-PA
    Kmn1-PB
    Nsl1-related protein
    l(1)G0237
    lethal (1) G0237

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      11571383..11572442 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132501.3 → NP_572729.1  kinetochore Mis12-Ndc80 network component 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572729.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B8Q853, B8Q859, Q9VYX4
      Related
      FBpp0073386

    2. NM_001316625.1 → NP_001303554.1  kinetochore Mis12-Ndc80 network component 1, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      B8Q853, B8Q859, Q9VYX4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VYX4 Q9VYX4

    Gene LinkOut

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