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    mthl14 methuselah-like 14 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 318046, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mthl14provided by FlyBase
    Official Full Name
    methuselah-like 14provided by FlyBase
    Primary source
    FLYBASE:FBgn0052476
    Locus tag
    Dmel_CG32476
    See related
    AllianceGenome:FB:FBgn0052476
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE31310; CG32476; Dmel\CG32476; Mthl14
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Is expressed in adult head; embryonic/larval foregut; and embryonic/larval midgut. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mthl14 in Genome Data Viewer
    Location:
    61B3-61B3; 3-1 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (247491..250305)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (247491..250305)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Enhancer of bithorax Neighboring gene DISCO Interacting Protein 2 Neighboring gene ncRNA Neighboring gene Tudor staphylococcal nuclease Neighboring gene wee Augmin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Massive parallel expansions of Methuselah/Methuselah-like receptors in schizophoran Diptera. Friedrich M, et al. J Exp Zool B Mol Dev Evol, 2018 Sep. PMID 30058118
    2. Miple1 and miple2 encode a family of MK/PTN homologues in Drosophila melanogaster. Englund C, et al. Dev Genes Evol, 2006 Jan. PMID 16220264
    3. Gene Ages, Nomenclatures, and Functional Diversification of the Methuselah/Methuselah-Like GPCR Family in Drosophila and Tribolium. Friedrich M, et al. J Exp Zool B Mol Dev Evol, 2016 Dec. PMID 28074535
    4. Methuselah/Methuselah-like G protein-coupled receptors constitute an ancient metazoan gene family. de Mendoza A, et al. Sci Rep, 2016 Feb 26. PMID 26915348, Free PMC Article
    5. The Drosophila melanogaster methuselah gene: a novel gene with ancient functions. Araújo AR, et al. PLoS One, 2013. PMID 23696853, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G protein-coupled receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    methuselah-like 14
    Names
    CG32476-PA
    mthl14-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      247491..250305
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167821.3 → NP_728509.1  methuselah-like 14 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728509.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SYV9
      Related
      FBpp0072402
      Conserved Domains (1) summary
      cd15039
      Location:239 → 512
      7tmB3_Methuselah-like; Methuselah-like subfamily B3, member of the class B family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SYV9.1 Q8SYV9

    Gene LinkOut

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