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    Plod procollagen lysyl hydroxylase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39265, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Plodprovided by FlyBase
    Official Full Name
    procollagen lysyl hydroxylaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036147
    Locus tag
    Dmel_CG6199
    See related
    AllianceGenome:FB:FBgn0036147
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:ParkEST325; anon-WO0118547.416; CG6199; Dmel\CG6199; dplod; dPlod; LH3; plod; RE-H
    Summary
    Enables procollagen galactosyltransferase activity and procollagen glucosyltransferase activity. Involved in growth of a germarium-derived egg chamber. Located in endoplasmic reticulum; extracellular space; and perinuclear region of cytoplasm. Is expressed in several structures, including adult head; embryonic/larval anal pad; embryonic/larval hemocyte; nurse cell; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome kyphoscoliotic type 1. Orthologous to several human genes including PLOD1 (procollagen-lysine,2-oxoglutarate 5-dioxygenase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Plod in Genome Data Viewer
    Location:
    68B1-68B1; 3-35 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11198166..11206016, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11191266..11199116, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Glucuronyltransferase P Neighboring gene uncharacterized protein Neighboring gene noktochor Neighboring gene Ubiquitin protein ligase E3A Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Whole-Genome Resequencing of Experimental Populations Reveals Polygenic Basis of Egg-Size Variation in Drosophila melanogaster. Jha AR, et al. Mol Biol Evol, 2015 Oct. PMID 26044351, Free PMC Article
    2. A Secreted Ig-Domain Protein Required in Both Astrocytes and Neurons for Regulation of Drosophila Night Sleep. Sengupta S, et al. Curr Biol, 2019 Aug 5. PMID 31353186, Free PMC Article
    3. The sex determination gene doublesex regulates expression and secretion of the basement membrane protein Collagen IV. Peng Q, et al. J Genet Genomics, 2022 Jul. PMID 35017121
    4. Characterisation of the Drosophila procollagen lysyl hydroxylase, dPlod. Bunt S, et al. Gene Expr Patterns, 2011 Jan-Feb. PMID 20888931, Free PMC Article
    5. Biosynthesis and assembly of the Collagen IV-like protein Pericardin in Drosophila melanogaster. Wilmes AC, et al. Biol Open, 2018 Apr 23. PMID 29685999, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables L-ascorbic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables procollagen galactosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables procollagen glucosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables procollagen-lysine 5-dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables procollagen-lysine 5-dioxygenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in collagen fibril organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in growth of a germarium-derived egg chamber IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    procollagen lysyl hydroxylase
    Names
    CG6199-PA
    CG6199-PB
    Plod-PA
    Plod-PB
    drosophila plod
    lysyl hydroxylase
    NP_648451.1
    NP_729687.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      11198166..11206016 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168452.2 → NP_729687.1  procollagen lysyl hydroxylase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729687.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q86NR6, Q8MSV4, Q9VTH0
      Related
      FBpp0075918
      Conserved Domains (2) summary
      smart00702
      Location:555 → 719
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      cl11394
      Location:303 → 395
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    2. NM_140194.2 → NP_648451.1  procollagen lysyl hydroxylase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648451.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q86NR6, Q8MSV4, Q9VTH0
      Related
      FBpp0075917
      Conserved Domains (2) summary
      smart00702
      Location:555 → 719
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      cl11394
      Location:303 → 395
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VTH0.1 Q9VTH0

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