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    miple1 midkine and pleiotrophin 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38047, updated on 9-Dec-2024

    Summary

    Official Symbol
    miple1provided by FlyBase
    Official Full Name
    midkine and pleiotrophin 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0027111
    Locus tag
    Dmel_CG1221
    See related
    AllianceGenome:FB:FBgn0027111
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey203; CG1221; Dmel\CG1221; miple; Miple
    Summary
    Enables heparin binding activity. Involved in determination of adult lifespan and mesoderm morphogenesis. Located in extracellular region. Is expressed in several structures, including embryonic ventral epidermis; embryonic/larval anterior midgut; ganglia; imaginal disc; and visceral muscle primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Try the new Transcript table

    Genomic context

    See miple1 in Genome Data Viewer
    Location:
    61B3-61B3; 3-1 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (267299..270336)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (267299..270336)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Tudor staphylococcal nuclease Neighboring gene ncRNA Neighboring gene mitochondrial ribosomal protein L17 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene midkine and pleiotrophin 2 Neighboring gene tiny tim 2

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables heparin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables heparin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables heparin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mesoderm morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mesoderm morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    midkine and pleiotrophin 1
    Names
    CG1221-PA
    CG1221-PB
    CG1221-PC
    miple
    miple1-PA
    miple1-PB
    miple1-PC

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      267299..270336
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274268.1NP_001261197.1  midkine and pleiotrophin 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261197.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SYA0, Q9W0S5, Q9Y0V9
      Conserved Domains (1) summary
      pfam01091
      Location:73124
      PTN_MK_C; PTN/MK heparin-binding protein family, C-terminal domain
    2. NM_138178.3NP_612022.1  midkine and pleiotrophin 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_612022.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SYA0, Q9W0S5, Q9Y0V9
      Related
      FBpp0072405
      Conserved Domains (1) summary
      pfam01091
      Location:73124
      PTN_MK_C; PTN/MK heparin-binding protein family, C-terminal domain
    3. NM_206225.2NP_995947.1  midkine and pleiotrophin 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995947.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SYA0, Q9W0S5, Q9Y0V9
      Conserved Domains (1) summary
      pfam01091
      Location:73124
      PTN_MK_C; PTN/MK heparin-binding protein family, C-terminal domain