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    Rpn13R Regulatory particle non-ATPase 13-related [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31433, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rpn13Rprovided by FlyBase
    Official Full Name
    Regulatory particle non-ATPase 13-relatedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029745
    Locus tag
    Dmel_CG6789
    See related
    AllianceGenome:FB:FBgn0029745
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6789; Dmel\CG6789
    Summary
    Predicted to enable endopeptidase activator activity; proteasome binding activity; and ubiquitin binding activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be part of proteasome regulatory particle, lid subcomplex. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rpn13R in Genome Data Viewer
    Location:
    4F1-4F1; 1-11 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (5131898..5132985)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (5025931..5027018)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44833 Neighboring gene ovo Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene rugose Neighboring gene long non-coding RNA:CR44834 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Duplicated proteasome subunit genes in Drosophila and their roles in spermatogenesis. Belote JM, et al. Heredity (Edinb), 2009 Jul. PMID 19277057
    2. Localization of the proteasomal ubiquitin receptors Rpn10 and Rpn13 by electron cryomicroscopy. Sakata E, et al. Proc Natl Acad Sci U S A, 2012 Jan 31. PMID 22215586, Free PMC Article
    3. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article
    4. A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Neely GG, et al. Cell, 2010 Apr 2. PMID 20371351, Free PMC Article
    5. A protein interaction map of Drosophila melanogaster. Giot L, et al. Science, 2003 Dec 5. PMID 14605208

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables endopeptidase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proteasome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome regulatory particle, lid subcomplex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome regulatory particle, lid subcomplex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    regulatory particle non-ATPase 13-related
    Names
    CG6789-PA
    Rpn13R-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      5131898..5132985
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_131977.2 → NP_572205.1  regulatory particle non-ATPase 13-related [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572205.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0ML33, C0ML36, C0ML40, Q9W4E6
      Related
      FBpp0070709
      Conserved Domains (2) summary
      cd13314
      Location:10 → 115
      PH_Rpn13; Pleckstrin homology-like domain of Regulatory Particle Non-ATPase 13
      pfam16550
      Location:204 → 312
      RPN13_C; UCH-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W4E6 Q9W4E6

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