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    Tret1-1 Trehalose transporter 1-1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36248, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tret1-1provided by FlyBase
    Official Full Name
    Trehalose transporter 1-1provided by FlyBase
    Primary source
    FLYBASE:FBgn0050035
    Locus tag
    Dmel_CG30035
    See related
    AllianceGenome:FB:FBgn0050035
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG30035; CG7797; CG7801; Dmel\CG30035; DmTret1-1; Tre T1; tret; Tret-1
    Summary
    Enables D-glucose transmembrane transporter activity and trehalose transmembrane transporter activity. Involved in D-glucose transmembrane transport and trehalose transport. Located in plasma membrane. Is expressed in several structures, including adult head; amnioserosa; embryonic/larval fat body; glial cell; and larval central nervous system. Orthologous to human SLC2A6 (solute carrier family 2 member 6) and SLC2A8 (solute carrier family 2 member 8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tret1-1 in Genome Data Viewer
    Location:
    48B6-48B7; 2-64 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11665768..11674782)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7553273..7562287)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Regulator of cullins 2 Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Methionine-CAT 1-2 Neighboring gene Trehalose transporter 1-2 Neighboring gene buffy Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Plasticity of Carbohydrate Transport at the Blood-Brain Barrier. McMullen E, et al. Front Behav Neurosci, 2020. PMID 33551766, Free PMC Article
    2. Glucose and trehalose metabolism through the cyclic pentose phosphate pathway shapes pathogen resistance and host protection in Drosophila. Kazek M, et al. PLoS Biol, 2024 May. PMID 38713712, Free PMC Article
    3. The trehalose transporter 1 gene sequence is conserved in insects and encodes proteins with different kinetic properties involved in trehalose import into peripheral tissues. Kanamori Y, et al. Insect Biochem Mol Biol, 2010 Jan. PMID 20035867
    4. Feedforward Regulation of Glucose Metabolism by Steroid Hormones Drives a Developmental Transition in Drosophila. Nishimura T. Curr Biol, 2020 Sep 21. PMID 32679096
    5. Molecular characterization of Tps1 and Treh genes in Drosophila and their role in body water homeostasis. Yoshida M, et al. Sci Rep, 2016 Jul 29. PMID 27469628, Free PMC Article

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables D-glucose transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sugar transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables trehalose transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in D-glucose transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in carbohydrate transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT involved_in lactose transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT involved_in maltose transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT involved_in sucrose transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in trehalose transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    trehalose transporter 1-1
    Names
    CG30035-PA
    CG30035-PB
    Tret1-1-PA
    Tret1-1-PB
    trehalose transporter
    trehalose transporter 1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      11665768..11674782
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136849.2 → NP_610693.1  trehalose transporter 1-1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610693.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1Z8N1, A9ZSY5, Q6NQZ8, Q86P59
      Related
      FBpp0087178
      Conserved Domains (2) summary
      cd06174
      Location:401 → 822
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00879
      Location:382 → 833
      SP; MFS transporter, sugar porter (SP) family

    2. NM_165845.2 → NP_725068.1  trehalose transporter 1-1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725068.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1Z8N1
      Related
      FBpp0087179
      Conserved Domains (2) summary
      cd06174
      Location:33 → 454
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam00083
      Location:31 → 467
      Sugar_tr; Sugar (and other) transporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z8N1.1 A1Z8N1

    Gene LinkOut

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