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    ND-B16.6 NADH dehydrogenase (ubiquinone) B16.6 subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31578, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ND-B16.6provided by FlyBase
    Official Full Name
    NADH dehydrogenase (ubiquinone) B16.6 subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029868
    Locus tag
    Dmel_CG3446
    See related
    AllianceGenome:FB:FBgn0029868
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3446; Dmel\CG3446; dNDUFA13; NB6M; NDUFA13
    Summary
    Predicted to be involved in mitochondrial respiratory chain complex I assembly. Part of respiratory chain complex I. Is expressed in adult head; adult heart; organism; and spermatozoon. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 28 and oncocytic carcinoma of the thyroid. Orthologous to human NDUFA13 (NADH:ubiquinone oxidoreductase subunit A13). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ND-B16.6 in Genome Data Viewer
    Location:
    5F2-5F2; 1-16 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6349016..6350401, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6243357..6244434, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene knockdown Neighboring gene swallow pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The yeast complex I equivalent NADH dehydrogenase rescues pink1 mutants. Vilain S, et al. PLoS Genet, 2012 Jan. PMID 22242018, Free PMC Article
    2. Metabolic disruption in Drosophila bang-sensitive seizure mutants. Fergestad T, et al. Genetics, 2006 Jul. PMID 16648587, Free PMC Article
    3. Immunopurification of Ago1 miRNPs selects for a distinct class of microRNA targets. Hong X, et al. Proc Natl Acad Sci U S A, 2009 Sep 1. PMID 19706460, Free PMC Article
    4. The membrane domain of respiratory complex I accumulates during muscle aging in Drosophila melanogaster. Hossain KFB, et al. Sci Rep, 2022 Dec 27. PMID 36575244, Free PMC Article
    5. Isoforms of the transcriptional cofactor SIN3 differentially regulate genes necessary for energy metabolism and cell survival. Mitra A, et al. Biochim Biophys Acta Mol Cell Res, 2022 Oct. PMID 35820484, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, NADH to ubiquinone IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mitochondrial respiratory chain complex I assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    part_of respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex I ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    NADH dehydrogenase (ubiquinone) B16.6 subunit
    Names
    CG3446-PA
    CG3446-PB
    CG3446-PC
    NADH ubiquinone oxidoreductase B16.6
    NADH-ubiquinone oxidoreductase B16.6 subunit
    NADH:ubiquinone oxidoreductase B16.6 subunit
    ND-B16.6-PA
    ND-B16.6-PB
    ND-B16.6-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      6349016..6350401 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001316630.1 → NP_001303559.1  NADH dehydrogenase (ubiquinone) B16.6 subunit, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W402
      Conserved Domains (1) summary
      pfam06212
      Location:9 → 140
      GRIM-19; GRIM-19 protein

    2. NM_132090.3 → NP_572318.1  NADH dehydrogenase (ubiquinone) B16.6 subunit, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572318.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W402
      Related
      FBpp0070885
      Conserved Domains (1) summary
      pfam06212
      Location:9 → 140
      GRIM-19; GRIM-19 protein

    3. NM_001298014.1 → NP_001284943.1  NADH dehydrogenase (ubiquinone) B16.6 subunit, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284943.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W402
      Conserved Domains (1) summary
      pfam06212
      Location:9 → 140
      GRIM-19; GRIM-19 protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W402 Q9W402

    Gene LinkOut

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