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    Ccs Copper chaperone for superoxide dismutase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 46035, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ccsprovided by FlyBase
    Official Full Name
    Copper chaperone for superoxide dismutaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0010531
    Locus tag
    Dmel_CG17753
    See related
    AllianceGenome:FB:FBgn0010531
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey231; CCD; CCS; CG-17753; CG17753; dCCS; DmCCS; Dmel\CG17753; l(2)03221
    Summary
    Enables superoxide dismutase copper chaperone activity. Involved in determination of adult lifespan; protein stabilization; and response to oxidative stress. Located in peroxisome. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human CCS (copper chaperone for superoxide dismutase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ccs in Genome Data Viewer
    Location:
    46F1-46F1; 2-62 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10121486..10122574, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6008991..6010079, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Phosphofructokinase Neighboring gene dampened Neighboring gene uncharacterized protein Neighboring gene gemini Neighboring gene antisense RNA:CR43467 Neighboring gene uncharacterized protein Neighboring gene Odorant receptor 46a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Targeting of copper-trafficking chaperones causes gene-specific systemic pathology in Drosophila melanogaster: prospective expansion of mutational landscapes that regulate tumor resistance to cisplatin. Theotoki EI, et al. Biol Open, 2019 Oct 15. PMID 31575544, Free PMC Article
    2. DJ-1 and SOD1 Act Independently in the Protection against Anoxia in Drosophila melanogaster. De Lazzari F, et al. Antioxidants (Basel), 2022 Aug 5. PMID 36009245, Free PMC Article
    3. Essential roles in development and pigmentation for the Drosophila copper transporter DmATP7. Norgate M, et al. Mol Biol Cell, 2006 Jan. PMID 16251357, Free PMC Article
    4. Superoxide dismutase evolution and life span regulation. Landis GN, et al. Mech Ageing Dev, 2005 Mar. PMID 15664623
    5. What can flies tell us about copper homeostasis? Southon A, et al. Metallomics, 2013 Oct. PMID 23903872

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables copper ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables copper ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables superoxide dismutase copper chaperone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables superoxide dismutase copper chaperone activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein stabilization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in removal of superoxide radicals IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in superoxide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    copper chaperone for superoxide dismutase
    Names
    CCS
    CG17753-PB
    CG17753-PC
    Ccs-PB
    Ccs-PC
    Cu-chaperone for superoxide dismutase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      10121486..10122574 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143772.5 → NP_652029.3  copper chaperone for superoxide dismutase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652029.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z850, Q9BLY4
      Conserved Domains (2) summary
      cd00305
      Location:66 → 217
      Cu-Zn_Superoxide_Dismutase; Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the ...
      cd00371
      Location:6 → 58
      HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...

    2. NM_001169637.3 → NP_001163108.1  copper chaperone for superoxide dismutase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163108.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JH26, Q9BLY4
      Conserved Domains (3) summary
      PLN02957
      Location:1 → 253
      PLN02957; copper, zinc superoxide dismutase
      cd00305
      Location:72 → 223
      Cu-Zn_Superoxide_Dismutase; Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the ...
      cd00371
      Location:5 → 64
      HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z850 A1Z850
    E1JH26 E1JH26
    Q9BLY4 Q9BLY4

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