Nup62 Nucleoporin 62kD [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Nup62provided by FlyBase
Official Full Name: Nucleoporin 62kDprovided by FlyBase
Primary source: FLYBASE:FBgn0034118
Locus tag: Dmel_CG6251
See related: AllianceGenome:FB:FBgn0034118
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG6251; Dmel\CG6251; nup62; p62
Summary: Enables chromatin DNA binding activity. Involved in chromosome attachment to the nuclear envelope; oocyte karyosome formation; and regulation of nucleus size. Located in chromatin and nuclear envelope. Is expressed in several structures, including adult head; adult heart; central brain primordium; embryonic/larval midgut primordium; and ganglia. Human ortholog(s) of this gene implicated in primary biliary cholangitis and striatonigral degeneration. Orthologous to several human genes including NUP62 (nucleoporin 62). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (16344377..16345828)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (12231882..12233333)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables chromatin DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of nuclear pore	IEA Inferred from Electronic Annotation more info
enables structural constituent of nuclear pore	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in RNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromosome attachment to the nuclear envelope	IGI Inferred from Genetic Interaction more info	PubMed
involved_in chromosome attachment to the nuclear envelope	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte karyosome formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in oocyte karyosome formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of nucleus size	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IMP Inferred from Mutant Phenotype more info	PubMed
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear pore	IEA Inferred from Electronic Annotation more info
part_of nuclear pore central transport channel	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear pore central transport channel	ISS Inferred from Sequence or Structural Similarity more info

Names: CG6251-PA; CG6251-PB; Nup62-PA; Nup62-PB; nucleoporin; nucleoporin 62

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