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    Nop60B Nucleolar protein at 60B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37873, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nop60Bprovided by FlyBase
    Official Full Name
    Nucleolar protein at 60Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0259937
    Locus tag
    Dmel_CG3333
    See related
    AllianceGenome:FB:FBgn0259937
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3333; DKC1; Dmel\CG3333; dUhg6; l(2)k05318; mfl; minifly; Nop60; nop60B; Nop60b; NOP60B; Nop60B/mfl; Nop60B/mnf; Uhg6
    Summary
    Predicted to enable pseudouridine synthase activity. Involved in RNA metabolic process; germ cell development; and wing disc development. Is active in nucleolus. Is expressed in several structures, including adult head; female germline cell; germarium; ovary; and wing disc. Used to study X-linked dyskeratosis congenita and dyskeratosis congenita. Human ortholog(s) of this gene implicated in X-linked dyskeratosis congenita; aplastic anemia; and dyskeratosis congenita. Orthologous to human DKC1 (dyskerin pseudouridine synthase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nop60B in Genome Data Viewer
    Location:
    60C1-60C2; 2-106 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24174877..24186343)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20062400..20073866)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene mitochondrial ribosomal protein S17 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene over compensating males Neighboring gene cytosolic 5'-nucleotidase IIIB

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila dyskerin is required for somatic stem cell homeostasis. Vicidomini R, et al. Sci Rep, 2017 Mar 23. PMID 28337032, Free PMC Article
    2. The Nop60B gene of Drosophila encodes an essential nucleolar protein that functions in yeast. Phillips B, et al. Mol Gen Genet, 1998 Oct. PMID 9829824
    3. Structure and function of the nucleolus. Scheer U, et al. Curr Opin Cell Biol, 1999 Jun. PMID 10395554
    4. Mutations in Nop60B, the Drosophila homolog of human dyskeratosis congenita 1, affect the maintenance of the germ-line stem cell lineage during spermatogenesis. Kauffman T, et al. Dev Biol, 2003 Jan 15. PMID 12645924
    5. Loss of Drosophila pseudouridine synthase triggers apoptosis-induced proliferation and promotes cell-nonautonomous EMT. Vicidomini R, et al. Cell Death Dis, 2015 Mar 26. PMID 25811802, Free PMC Article

    See all (99) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study demonstrates that either ubiquitous or escargot-driven dyskerin depletion specifically abolishes the formation of the intestinal imaginal islands, the transient stem cell niche, without any apparent effect on the other midgut cell types.
      Title: Drosophila dyskerin is required for somatic stem cell homeostasis.
    2. Pseudouridine synthase (diskerin,Mfl)depletion also causes disruption of adherens cell junctions and ectopic induction of JNK (c-Jun N-terminal kinase) and Mmp1 (matrix metalloproteinase-1) activity, leading to a significant epithelial reorganization
      Title: Loss of Drosophila pseudouridine synthase triggers apoptosis-induced proliferation and promotes cell-nonautonomous EMT.
    3. results expand repertoire of coding/non-coding transcripts derived from the gene encoding Drosophila pseudouridine synthase It exhibits complex interlaced organization.
      Title: The coding/non-coding overlapping architecture of the gene encoding the Drosophila pseudouridine synthase.
    4. Mutations in Nop60B, the Drosophila homolog of human dyskeratosis congenita 1, affect the maintenance of the germ-line stem cell lineage during spermatogenesis.
      Title: Mutations in Nop60B, the Drosophila homolog of human dyskeratosis congenita 1, affect the maintenance of the germ-line stem cell lineage during spermatogenesis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pseudouridine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pseudouridine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in box H/ACA sno(s)RNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in germ cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA pseudouridine synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pseudouridine synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pseudouridine synthesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA pseudouridine synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosome biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in snRNA pseudouridine synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in wing disc development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of box H/ACA snoRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of box H/ACA snoRNP complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nucleolar protein at 60B
    Names
    CG3333-PA
    CG3333-PB
    CG3333-PC
    CG3333-PF
    CG3333-PG
    Nop60B-PA
    Nop60B-PB
    Nop60B-PC
    Nop60B-PF
    Nop60B-PG
    Uhg6
    dUhg-like 6
    minifly

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24174877..24186343
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001169818.3 → NP_001163289.1  nucleolar protein at 60B, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163289.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8E745, O44081, Q0GLB4, Q0MVP1, Q8T408, Q9UAN8, Q9V3Z5
      UniProtKB/TrEMBL
      E1JGV6, H5V894
      Conserved Domains (4) summary
      cd02572
      Location:86 → 268
      PseudoU_synth_hDyskerin; Pseudouridine synthase, human dyskerin like
      TIGR00425
      Location:54 → 379
      CBF5; rRNA pseudouridine synthase, putative
      pfam01472
      Location:295 → 368
      PUA; PUA domain
      pfam08068
      Location:47 → 104
      DKCLD; DKCLD (NUC011) domain

    2. NM_001014547.4 → NP_001014547.1  nucleolar protein at 60B, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014547.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8E745, O44081, Q0GLB4, Q0MVP1, Q8T408, Q9UAN8, Q9V3Z5
      UniProtKB/TrEMBL
      E1JGV6, H5V894
      Conserved Domains (4) summary
      cd02572
      Location:86 → 268
      PseudoU_synth_hDyskerin; Pseudouridine synthase, human dyskerin like
      TIGR00425
      Location:54 → 379
      CBF5; rRNA pseudouridine synthase, putative
      pfam01472
      Location:295 → 368
      PUA; PUA domain
      pfam08068
      Location:47 → 104
      DKCLD; DKCLD (NUC011) domain

    3. NM_001169815.3 → NP_001163286.1  nucleolar protein at 60B, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163286.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8E745, O44081, Q0GLB4, Q0MVP1, Q8T408, Q9UAN8, Q9V3Z5
      UniProtKB/TrEMBL
      E1JGV6, H5V894
      Conserved Domains (4) summary
      cd02572
      Location:86 → 268
      PseudoU_synth_hDyskerin; Pseudouridine synthase, human dyskerin like
      TIGR00425
      Location:54 → 379
      CBF5; rRNA pseudouridine synthase, putative
      pfam01472
      Location:295 → 368
      PUA; PUA domain
      pfam08068
      Location:47 → 104
      DKCLD; DKCLD (NUC011) domain

    4. NM_001259561.2 → NP_001246490.1  nucleolar protein at 60B, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246490.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K8B2
      Conserved Domains (2) summary
      pfam08068
      Location:47 → 104
      DKCLD; DKCLD (NUC011) domain
      cl00130
      Location:86 → 214
      PseudoU_synth; Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi)

    5. NM_080381.5 → NP_525120.1  nucleolar protein at 60B, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_525120.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8E745, O44081, Q0GLB4, Q0MVP1, Q8T408, Q9UAN8, Q9V3Z5
      UniProtKB/TrEMBL
      E1JGV6, H5V894
      Related
      FBpp0072166
      Conserved Domains (4) summary
      cd02572
      Location:86 → 268
      PseudoU_synth_hDyskerin; Pseudouridine synthase, human dyskerin like
      TIGR00425
      Location:54 → 379
      CBF5; rRNA pseudouridine synthase, putative
      pfam01472
      Location:295 → 368
      PUA; PUA domain
      pfam08068
      Location:47 → 104
      DKCLD; DKCLD (NUC011) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K8B2 A0A0B4K8B2
    E1JGV6 E1JGV6
    O44081.1 O44081

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