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    Vps37c vacuolar protein sorting 37C [ Mus musculus (house mouse) ]

    Gene ID: 107305, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Vps37cprovided by MGI
    Official Full Name
    vacuolar protein sorting 37Cprovided by MGI
    Primary source
    MGI:MGI:2147661
    See related
    Ensembl:ENSMUSG00000048832 AllianceGenome:MGI:2147661
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5730409F24Rik
    Summary
    Predicted to enable calcium-dependent protein binding activity. Predicted to be involved in protein targeting to membrane; protein targeting to vacuole; and ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Predicted to be located in late endosome membrane. Predicted to be part of ESCRT I complex. Is expressed in glossopharyngeal ganglion; liver lobe; trigeminal ganglion; and vibrissa. Orthologous to human VPS37C (VPS37C subunit of ESCRT-I). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in colon adult (RPKM 20.1), adrenal adult (RPKM 16.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Vps37c in Genome Data Viewer
    Location:
    19 A; 19 7.16 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (10666095..10691992)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (10688735..10714628)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene pepsinogen 5, group I Neighboring gene RIKEN cDNA 2210404E10 gene Neighboring gene CD5 antigen Neighboring gene RIKEN cDNA A430093F15 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873
    2. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
    3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium-dependent protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting to vacuole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of ESCRT I complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ESCRT I complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ESCRT I complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    vacuolar protein sorting-associated protein 37C
    Names
    ESCRT-I complex subunit VPS37C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001361958.1 → NP_001348887.1  vacuolar protein sorting-associated protein 37C isoform 1

      Status: VALIDATED

      Source sequence(s)
      AK158833, AK159309, BX635445
      Consensus CDS
      CCDS29585.1
      UniProtKB/Swiss-Prot
      Q3TY76, Q8R105
      Related
      ENSMUSP00000158500.2, ENSMUST00000235927.2
      Conserved Domains (2) summary
      PHA03247
      Location:184 → 313
      PHA03247; large tegument protein UL36; Provisional
      pfam07200
      Location:5 → 149
      Mod_r; Modifier of rudimentary (Mod(r)) protein

    2. NM_001361959.1 → NP_001348888.1  vacuolar protein sorting-associated protein 37C isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK158833, BX635445
      Conserved Domains (2) summary
      PHA03247
      Location:76 → 205
      PHA03247; large tegument protein UL36; Provisional
      pfam07200
      Location:2 → 41
      Mod_r; Modifier of rudimentary (Mod(r)) protein

    3. NM_001361960.1 → NP_001348889.1  vacuolar protein sorting-associated protein 37C isoform 3

      Status: VALIDATED

      Source sequence(s)
      AK150606, AK158833, BX635445
      Consensus CDS
      CCDS89345.1
      UniProtKB/TrEMBL
      A0A494BAR3
      Related
      ENSMUSP00000158200.2, ENSMUST00000235921.2
      Conserved Domains (1) summary
      pfam07200
      Location:5 → 119
      Mod_r; Modifier of rudimentary (Mod(r)) protein

    4. NM_001361961.1 → NP_001348890.1  vacuolar protein sorting-associated protein 37C isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC132247
      Consensus CDS
      CCDS29585.1
      UniProtKB/Swiss-Prot
      Q3TY76, Q8R105
      Conserved Domains (2) summary
      PHA03247
      Location:184 → 313
      PHA03247; large tegument protein UL36; Provisional
      pfam07200
      Location:5 → 149
      Mod_r; Modifier of rudimentary (Mod(r)) protein

    5. NM_001361962.1 → NP_001348891.1  vacuolar protein sorting-associated protein 37C isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC132247
      Consensus CDS
      CCDS29585.1
      UniProtKB/Swiss-Prot
      Q3TY76, Q8R105
      Conserved Domains (2) summary
      PHA03247
      Location:184 → 313
      PHA03247; large tegument protein UL36; Provisional
      pfam07200
      Location:5 → 149
      Mod_r; Modifier of rudimentary (Mod(r)) protein

    6. NM_001361963.1 → NP_001348892.1  vacuolar protein sorting-associated protein 37C isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC132247
      Conserved Domains (2) summary
      PHA03247
      Location:76 → 205
      PHA03247; large tegument protein UL36; Provisional
      pfam07200
      Location:2 → 41
      Mod_r; Modifier of rudimentary (Mod(r)) protein

    7. NM_001361964.1 → NP_001348893.1  vacuolar protein sorting-associated protein 37C isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC132247, AK159309, BX635445, CO426419
      Consensus CDS
      CCDS29585.1
      UniProtKB/Swiss-Prot
      Q3TY76, Q8R105
      Conserved Domains (2) summary
      PHA03247
      Location:184 → 313
      PHA03247; large tegument protein UL36; Provisional
      pfam07200
      Location:5 → 149
      Mod_r; Modifier of rudimentary (Mod(r)) protein

    8. NM_181403.3 → NP_852068.1  vacuolar protein sorting-associated protein 37C isoform 1

      See identical proteins and their annotated locations for NP_852068.1

      Status: VALIDATED

      Source sequence(s)
      AC132247
      Consensus CDS
      CCDS29585.1
      UniProtKB/Swiss-Prot
      Q3TY76, Q8R105
      Related
      ENSMUSP00000085264.6, ENSMUST00000087951.7
      Conserved Domains (2) summary
      PHA03247
      Location:184 → 313
      PHA03247; large tegument protein UL36; Provisional
      pfam07200
      Location:5 → 149
      Mod_r; Modifier of rudimentary (Mod(r)) protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      10666095..10691992
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161381.1 → XP_036017274.1  vacuolar protein sorting-associated protein 37C isoform X2

      Conserved Domains (2) summary
      PHA03247
      Location:76 → 205
      PHA03247; large tegument protein UL36; Provisional
      pfam07200
      Location:2 → 41
      Mod_r; Modifier of rudimentary (Mod(r)) protein

    2. XM_036161382.1 → XP_036017275.1  vacuolar protein sorting-associated protein 37C isoform X2

      Conserved Domains (2) summary
      PHA03247
      Location:76 → 205
      PHA03247; large tegument protein UL36; Provisional
      pfam07200
      Location:2 → 41
      Mod_r; Modifier of rudimentary (Mod(r)) protein

    3. XM_006526574.5 → XP_006526637.1  vacuolar protein sorting-associated protein 37C isoform X1

      See identical proteins and their annotated locations for XP_006526637.1

      UniProtKB/Swiss-Prot
      Q3TY76, Q8R105
      Conserved Domains (2) summary
      PHA03247
      Location:184 → 313
      PHA03247; large tegument protein UL36; Provisional
      pfam07200
      Location:5 → 149
      Mod_r; Modifier of rudimentary (Mod(r)) protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R105.1 GenPept UniProtKB/Swiss-Prot:Q8R105

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