Oseg4 Outer segment 4 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Oseg4provided by FlyBase
Official Full Name: Outer segment 4provided by FlyBase
Primary source: FLYBASE:FBgn0035264
Locus tag: Dmel_CG2069
See related: AllianceGenome:FB:FBgn0035264
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG2069; cytC40; Dmel\CG2069; IFT121; OSEG; oseg4; OSEG4; Wdr35; WDR35
Summary: Involved in cilium assembly and positive regulation of canonical Wnt signaling pathway. Located in non-motile cilium. Is expressed in several structures, including Malpighian tubule primordium; central brain primordium; epithelium; gut section; and sensory organ cell. Human ortholog(s) of this gene implicated in Ellis-Van Creveld syndrome; cranioectodermal dysplasia 2; and short-rib thoracic dysplasia 7 with or without polydactyly. Orthologous to human WDR35 (WD repeat domain 35). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 62B1-62B1; 3-1.0 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (1730993..1735767, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (1730993..1735767, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Oseg4 (WDR35), is also required for anterograde movement in distal cilia.
Title: Time-Lapse Live-Cell Imaging Reveals Dual Function of Oseg4, Drosophila WDR35, in Ciliary Protein Trafficking.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Process	Evidence Code	Pubs
involved_in cilium assembly	IEA Inferred from Electronic Annotation more info
involved_in cilium assembly	IEP Inferred from Expression Pattern more info	PubMed
involved_in intraciliary retrograde transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in non-motile cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in non-motile cilium assembly	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to cilium	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of intraciliary transport particle A	IBA Inferred from Biological aspect of Ancestor more info
part_of intraciliary transport particle A	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in non-motile cilium	IBA Inferred from Biological aspect of Ancestor more info
located_in non-motile cilium	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: outer segment 4

Names: CG2069-PA; CG2069-PB; Oseg4-PA; Oseg4-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

1730993..1735767 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_139396.4 → NP_647653.1 outer segment 4, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_647653.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9W097

Related

FBpp0072679

Conserved Domains (6) summary

COG2319
Location:7 → 217

WD40; WD40 repeat [General function prediction only]

sd00006
Location:815 → 838

TPR; TPR repeat [structural motif]

pfam07321
Location:877 → 980

YscO; Type III secretion protein YscO

pfam12013
Location:1163 → 1188

DUF3505; Protein of unknown function (DUF3505)

sd00039
Location:19 → 70

7WD40; WD40 repeat [structural motif]

cl02567
Location:18 → 242

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001274349.1 → NP_001261278.1 outer segment 4, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261278.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9W097

Conserved Domains (6) summary

COG2319
Location:7 → 217

WD40; WD40 repeat [General function prediction only]

sd00006
Location:815 → 838

TPR; TPR repeat [structural motif]

pfam07321
Location:877 → 980

YscO; Type III secretion protein YscO

pfam12013
Location:1163 → 1188

DUF3505; Protein of unknown function (DUF3505)

sd00039
Location:19 → 70

7WD40; WD40 repeat [structural motif]

cl02567
Location:18 → 242

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...