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    Lipt1 Lipoyltransferase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36795, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Lipt1provided by FlyBase
    Official Full Name
    Lipoyltransferase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0265178
    Locus tag
    Dmel_CG44243
    See related
    AllianceGenome:FB:FBgn0265178
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG44243; CG8446; Dmel\CG44243
    Summary
    Predicted to enable lipoyltransferase activity. Predicted to be involved in protein lipoylation. Predicted to be active in mitochondrion. Is expressed in several structures, including embryonic anal pad; gut section; larval muscle cell; larval muscle system; and posterior midgut primordium. Orthologous to human LIPT1 (lipoyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Lipt1 in Genome Data Viewer
    Location:
    52F7-52F8; 2-78 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16197042..16199555)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12084547..12087060)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene clueless Neighboring gene calypso Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene SH2 ankyrin repeat kinase Neighboring gene transfer RNA:Glutamine-CTG 1-1 Neighboring gene mrj Neighboring gene transfer RNA:Glutamic acid-TTC 1-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Protein interaction mapping: a Drosophila case study. Formstecher E, et al. Genome Res, 2005 Mar. PMID 15710747, Free PMC Article
    2. Transcriptomic analysis of inbreeding depression in cold-sensitive Drosophila melanogaster shows upregulation of the immune response. Vermeulen CJ, et al. J Evol Biol, 2013 Sep. PMID 23944235
    3. A protein complex network of Drosophila melanogaster. Guruharsha KG, et al. Cell, 2011 Oct 28. PMID 22036573, Free PMC Article
    4. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article
    5. A protein interaction map of Drosophila melanogaster. Giot L, et al. Science, 2003 Dec 5. PMID 14605208

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables lipoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipoyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein lipoylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    lipoyltransferase 1
    Names
    CG44243-PA
    CG44243-PB
    Lipt1-PA
    Lipt1-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16197042..16199555
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001202029.2 → NP_001188958.1  lipoyltransferase 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188958.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SX78, Q9V7K4
      Conserved Domains (2) summary
      TIGR00545
      Location:60 → 380
      lipoyltrans; lipoyltransferase and lipoate-protein ligase
      COG0095
      Location:63 → 311
      LplA; Lipoate-protein ligase A [Coenzyme transport and metabolism]

    2. NM_137253.5 → NP_611097.2  lipoyltransferase 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611097.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SX78, Q9V7K4
      Related
      FBpp0308232
      Conserved Domains (2) summary
      TIGR00545
      Location:60 → 380
      lipoyltrans; lipoyltransferase and lipoate-protein ligase
      COG0095
      Location:63 → 311
      LplA; Lipoate-protein ligase A [Coenzyme transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SX78 Q8SX78

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