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    ome omega [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44297, updated on 9-Dec-2024

    Summary

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    Official Symbol
    omeprovided by FlyBase
    Official Full Name
    omegaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0259175
    Locus tag
    Dmel_CG42280
    See related
    AllianceGenome:FB:FBgn0259175
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:LD21715; CG17705; CG32143; CG32145; CG42280; CG9370; Dmel\CG42280; LD21715; Ome; OMe
    Old locus tag
    Dmel_CG32143; Dmel_CG32145
    Summary
    Enables dipeptidyl-peptidase activity. Involved in proteolysis. Predicted to be active in plasma membrane. Is expressed in adult head; embryonic foregut sensory structure; gland; and gut section. Human ortholog(s) of this gene implicated in Middle East respiratory syndrome; amyotrophic lateral sclerosis; autosomal dominant intellectual developmental disorder 33; spinal muscular atrophy; and type 2 diabetes mellitus. Orthologous to human DPP4 (dipeptidyl peptidase 4); DPP6 (dipeptidyl peptidase like 6); and FAP (fibroblast activation protein alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ome in Genome Data Viewer
    Location:
    70E7-70F4; 3-42 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (14672839..14747868)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (14665939..14740968)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene dally-like Neighboring gene long non-coding RNA:CR45888 Neighboring gene transfer RNA:initiator Methionine-CAT 1-4 Neighboring gene transfer RNA:initiator Methionine-CAT 1-5 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Dynein axonemal assembly factor 6 Neighboring gene goddard Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Trithorax-like Neighboring gene tRNA splicing endonuclease subunit 34

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The cuticle proteins of Drosophila melanogaster: genetic localization of a second cluster of third-instar genes. Chihara CJ, et al. Genetics, 1986 Oct. PMID 3095183, Free PMC Article
    2. Identification and partial characterization of the enzyme of omega: one of five putative DPP IV genes in Drosophila melanogaster. Chihara CJ, et al. J Insect Sci, 2005 Nov 2. PMID 17119608, Free PMC Article
    3. Global analysis of trans-splicing in Drosophila. McManus CJ, et al. Proc Natl Acad Sci U S A, 2010 Jul 20. PMID 20615941, Free PMC Article
    4. Computational identification of developmental enhancers: conservation and function of transcription factor binding-site clusters in Drosophila melanogaster and Drosophila pseudoobscura. Berman BP, et al. Genome Biol, 2004. PMID 15345045, Free PMC Article
    5. An old weapon with a new function: PIWI-interacting RNAs in neurodegenerative diseases. Huang X, et al. Transl Neurodegener, 2021 Mar 8. PMID 33685517, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Chromosome mapping and expression studies of ome are reported.
      Title: Identification and partial characterization of the enzyme of omega: one of five putative DPP IV genes in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    mobile_element

    • Loc: 14721232-14723021 mobile_element_type = transposon:Rt1b{}999
    • Loc: 14725654-14728582 mobile_element_type = transposon:Doc{}1000

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables dipeptidyl-peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dipeptidyl-peptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serine hydrolase activity HDA PubMed 
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    omega
    Names
    CG42280-PE
    CG42280-PF
    CG42280-PG
    CG42280-PH
    ome-PE
    ome-PF
    ome-PG
    ome-PH
    NP_001097606.1
    NP_001137955.1
    NP_001261844.1
    NP_524739.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      14672839..14747868
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001144483.2 → NP_001137955.1  omega, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137955.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q29R16
      Conserved Domains (4) summary
      COG1506
      Location:644 → 915
      DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
      pfam00326
      Location:711 → 916
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:250 → 622
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
      pfam10500
      Location:18 → 150
      SR-25; Nuclear RNA-splicing-associated protein

    2. NM_001104136.2 → NP_001097606.1  omega, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097606.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A2RVG6
      Conserved Domains (3) summary
      COG1073
      Location:882 → 1028
      FrsA; Fermentation-respiration switch protein FrsA, has esterase activity, DUF1100 family [Signal transduction mechanisms]
      pfam00326
      Location:828 → 1033
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:367 → 739
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    3. NM_080000.4 → NP_524739.1  omega, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524739.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VUH1
      Related
      FBpp0288925
      Conserved Domains (3) summary
      COG1506
      Location:523 → 794
      DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
      pfam00326
      Location:590 → 795
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:129 → 501
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    4. NM_001274915.1 → NP_001261844.1  omega, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261844.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCH6
      Conserved Domains (3) summary
      COG1506
      Location:505 → 776
      DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
      pfam00326
      Location:572 → 777
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:111 → 483
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2RVG6 A2RVG6
    M9PCH6 M9PCH6
    Q29R16 Q29R16
    Q9VUH1 Q9VUH1

    Gene LinkOut

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