EloB Elongin B [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: EloBprovided by FlyBase
Official Full Name: Elongin Bprovided by FlyBase
Primary source: FLYBASE:FBgn0023212
Locus tag: Dmel_CG4204
See related: AllianceGenome:FB:FBgn0023212
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG4204; Dmel\CG4204; Elo-B; Elongin-B
Summary: Involved in several processes, including imaginal disc-derived wing vein specification; larval somatic muscle development; and negative regulation of receptor signaling pathway via JAK-STAT. Part of Cul2-RING ubiquitin ligase complex and elongin complex. Is expressed in several structures, including adult head; adult heart; anterior endoderm; embryonic/larval midgut primordium; and mesoderm. Orthologous to human ELOB (elongin B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (20578222..20579850, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (16403944..16405572, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Process	Evidence Code	Pubs
involved_in imaginal disc-derived wing vein specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in imaginal disc-derived wing vein specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval somatic muscle development	IEP Inferred from Expression Pattern more info	PubMed
involved_in larval somatic muscle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of receptor signaling pathway via JAK-STAT	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription elongation by RNA polymerase II	IC Inferred by Curator more info	PubMed
involved_in transcription elongation by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in viral process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Cul2-RING ubiquitin ligase complex	IPI Inferred from Physical Interaction more info	PubMed
part_of VCB complex	IBA Inferred from Biological aspect of Ancestor more info
part_of VCB complex	IEA Inferred from Electronic Annotation more info
part_of elongin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of elongin complex	IDA Inferred from Direct Assay more info	PubMed
part_of elongin complex	IEA Inferred from Electronic Annotation more info

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The following sections contain reference sequences that belong to a specific genome build. Explain