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    CG3436 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33180, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG3436provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031229
    Locus tag
    Dmel_CG3436
    See related
    AllianceGenome:FB:FBgn0031229
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG3436
    Summary
    Predicted to enable RNA binding activity. Involved in mitotic cell cycle. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in several structures, including adult head; anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; and ganglia. Orthologous to human SNRNP40 (small nuclear ribonucleoprotein U5 subunit 40). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG3436 in Genome Data Viewer
    Location:
    21B3-21B3; 2-0.5 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (156029..157666)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (156029..157666)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase (ubiquinone) 15 kDa subunit Neighboring gene uncharacterized protein Neighboring gene Pseudouridine synthase 10 Neighboring gene uncharacterized protein Neighboring gene split ends

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome-wide DNA replication profile for Drosophila melanogaster: a link between transcription and replication timing. Schübeler D, et al. Nat Genet, 2002 Nov. PMID 12355067
    2. Drosophila valois encodes a divergent WD protein that is required for Vasa localization and Oskar protein accumulation. Cavey M, et al. Development, 2005 Feb. PMID 15634703
    3. Drosophila MFAP1 is required for pre-mRNA processing and G2/M progression. Andersen DS, et al. J Biol Chem, 2008 Nov 7. PMID 18765666, Free PMC Article
    4. Orb2 enables rare-codon-enriched mRNA expression during Drosophila neuron differentiation. Stewart RK, et al. Nat Commun, 2024 Jun 20. PMID 38902233, Free PMC Article
    5. Regulation of microtubule assembly and organization in mitosis by the AAA+ ATPase Pontin. Ducat D, et al. Mol Biol Cell, 2008 Jul. PMID 18463163, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mitotic cell cycle HMP PubMed 
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome HDA PubMed 
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of precatalytic spliceosome HDA PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG3436-PA
    CG3436-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      156029..157666
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298614.1 → NP_001285543.1  uncharacterized protein Dmel_CG3436, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285543.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VPL0
      Conserved Domains (3) summary
      COG2319
      Location:19 → 346
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:50 → 342
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:58 → 96
      7WD40; WD40 repeat [structural motif]

    2. NM_134657.3 → NP_608501.1  uncharacterized protein Dmel_CG3436, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608501.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VPL0
      Related
      FBpp0077778
      Conserved Domains (3) summary
      COG2319
      Location:19 → 346
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:50 → 342
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:58 → 96
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VPL0 Q9VPL0

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