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    RhoGAP1A Rho GTPase activating protein at 1A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 5740235, updated on 17-Dec-2024

    Summary

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    Official Symbol
    RhoGAP1Aprovided by FlyBase
    Official Full Name
    Rho GTPase activating protein at 1Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0025836
    Locus tag
    Dmel_CG40494
    See related
    AllianceGenome:FB:FBgn0025836
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BCR; CG17617; CG17960; CG40453; CG40494; Dmel\CG40494; EG:23E12.2; EG:23E12.5; RhoGAP; rhoGAP1A
    Old locus tag
    Dmel_CG00000
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Involved in Golgi organization and negative regulation of cell size. Predicted to be active in membrane. Is expressed in several structures, including adult head; embryonic/larval midgut; ganglia; gastric caecum; and germline cell. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; chronic myeloid leukemia; and leukemia. Orthologous to several human genes including BCR (BCR activator of RhoGEF and GTPase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See RhoGAP1A in Genome Data Viewer
    Location:
    1A1-1A1; 1-0 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (127449..140340)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (23836..36727)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR40469 Neighboring gene uncharacterized protein Neighboring gene mir-4915 stem loop Neighboring gene long non-coding RNA:CR45473 Neighboring gene uncharacterized protein Neighboring gene trynity

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inference of RhoGAP/GTPase regulation using single-cell morphological data from a combinatorial RNAi screen. Nir O, et al. Genome Res, 2010 Mar. PMID 20144944, Free PMC Article
    2. Cross-talk between Rho and Rac GTPases drives deterministic exploration of cellular shape space and morphological heterogeneity. Sailem H, et al. Open Biol, 2014 Jan 22. PMID 24451547, Free PMC Article
    3. Recombination, dominance and selection on amino acid polymorphism in the Drosophila genome: contrasting patterns on the X and fourth chromosomes. Sheldahl LA, et al. Genetics, 2003 Nov. PMID 14668375, Free PMC Article
    4. Branch-restricted localization of phosphatase Prl-1 specifies axonal synaptogenesis domains. Urwyler O, et al. Science, 2019 May 3. PMID 31048465
    5. Feedback inhibition of actin on Rho mediates content release from large secretory vesicles. Segal D, et al. J Cell Biol, 2018 May 7. PMID 29496739, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    mobile_element

    • Loc: 130043-130141 mobile_element_type = transposon:INE-1{}4621
    • Loc: 130273-130671 mobile_element_type = transposon:INE-1{}4623
    • Loc: 135061-135784 mobile_element_type = transposon:INE-1{}4645

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cell size IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of Rho protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Rho GTPase activating protein at 1A
    Names
    CG40494-PA
    CG40494-PB
    CG40494-PC
    CG40494-PD
    CG40494-PE
    CG40494-PF
    RhoGAP1A-PA
    RhoGAP1A-PB
    RhoGAP1A-PC
    RhoGAP1A-PD
    RhoGAP1A-PE
    RhoGAP1A-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      127449..140340
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001297796.1 → NP_001284725.1  Rho GTPase activating protein at 1A, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284725.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JC00
      Conserved Domains (4) summary
      smart00325
      Location:675 → 857
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd13368
      Location:851 → 1037
      PH_BCR_arthropod; Breakpoint Cluster Region-related pleckstrin homology (PH) domain
      cl02570
      Location:1203 → 1398
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      cl14603
      Location:1079 → 1187
      C2; C2 domain

    2. NM_001297795.1 → NP_001284724.1  Rho GTPase activating protein at 1A, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284724.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2J9V9
      Conserved Domains (4) summary
      smart00325
      Location:673 → 855
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd13368
      Location:849 → 1035
      PH_BCR_arthropod; Breakpoint Cluster Region-related pleckstrin homology (PH) domain
      cl02570
      Location:1201 → 1396
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      cl14603
      Location:1077 → 1185
      C2; C2 domain

    3. NM_001103385.2 → NP_001096855.1  Rho GTPase activating protein at 1A, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001096855.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q29QE1
      Conserved Domains (4) summary
      smart00325
      Location:674 → 856
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd13368
      Location:850 → 1036
      PH_BCR_arthropod; Breakpoint Cluster Region-related pleckstrin homology (PH) domain
      cl02570
      Location:1202 → 1397
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      cl14603
      Location:1078 → 1186
      C2; C2 domain

    4. NM_001103386.2 → NP_001096856.1  Rho GTPase activating protein at 1A, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001096856.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q29QE1
      Conserved Domains (4) summary
      smart00325
      Location:674 → 856
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd13368
      Location:850 → 1036
      PH_BCR_arthropod; Breakpoint Cluster Region-related pleckstrin homology (PH) domain
      cl02570
      Location:1202 → 1397
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      cl14603
      Location:1078 → 1186
      C2; C2 domain

    5. NM_001169155.1 → NP_001162626.1  Rho GTPase activating protein at 1A, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162626.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C1C560
      Conserved Domains (3) summary
      smart00325
      Location:366 → 548
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd13368
      Location:542 → 728
      PH_BCR_arthropod; Breakpoint Cluster Region-related pleckstrin homology (PH) domain
      cl14603
      Location:770 → 878
      C2; C2 domain

    6. NM_001297797.1 → NP_001284726.1  Rho GTPase activating protein at 1A, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284726.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C1C560
      Conserved Domains (3) summary
      smart00325
      Location:366 → 548
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd13368
      Location:542 → 728
      PH_BCR_arthropod; Breakpoint Cluster Region-related pleckstrin homology (PH) domain
      cl14603
      Location:770 → 878
      C2; C2 domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    C1C560 C1C560
    O96833 O96833
    Q29QE1 Q29QE1
    Q6W434 Q6W434
    Q6W435 Q6W435
    Q6W436 Q6W436
    Q6W437 Q6W437
    Q6W453 Q6W453
    Q6W456 Q6W456
    Q8MSA6 Q8MSA6
    Q95TE3 Q95TE3
    Q9XZS6 Q9XZS6
    X2J9V9 X2J9V9
    X2JC00 X2JC00

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