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    Xpc Xeroderma pigmentosum, complementation group C [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36697, updated on 9-Dec-2024

    Summary

    Official Symbol
    Xpcprovided by FlyBase
    Official Full Name
    Xeroderma pigmentosum, complementation group Cprovided by FlyBase
    Primary source
    FLYBASE:FBgn0004698
    Locus tag
    Dmel_CG8153
    See related
    AllianceGenome:FB:FBgn0004698
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8153; DhR4; DhXPC; Dmel\CG8153; DmXPC; Mus 210; mus(2)201; mus(2)201G1; mus(2)201[GI]; mus201[G1]; mus210; Mus210; mus212; XPC; Xpcc; XPC[DM]
    Summary
    Predicted to enable damaged DNA binding activity and single-stranded DNA binding activity. Involved in meiotic mismatch repair involved in reciprocal meiotic recombination. Predicted to be located in cytosol and nucleus. Predicted to be part of XPC complex and nucleotide-excision repair factor 2 complex. Predicted to be active in cytoplasm. Is expressed in head mesoderm anlage; organism; and trunk mesoderm anlage. Human ortholog(s) of this gene implicated in pancreatic cancer; serous cystadenocarcinoma; xeroderma pigmentosum; and xeroderma pigmentosum group C. Orthologous to human XPC (XPC complex subunit, DNA damage recognition and repair factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Xpc in Genome Data Viewer
    Location:
    51F4-51F5; 2-74 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15311510..15318239)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11199015..11205744)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Transient receptor potential cation channel, subfamily M Neighboring gene NADH dehydrogenase (ubiquinone) 51 kDa subunit-like 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ADP ribosylation factor 6 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables damaged DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables damaged DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables damaged DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in meiotic mismatch repair involved in reciprocal meiotic recombination IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in mismatch repair IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in nucleotide-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in nucleotide-excision repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nucleotide-excision repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of XPC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of nucleotide-excision repair factor 2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    xeroderma pigmentosum, complementation group C
    Names
    CG8153-PA
    CG8153-PC
    CG8153-PD
    Xpc-PA
    Xpc-PC
    Xpc-PD
    mus210
    mutagen-sensitive 210
    xeroderma pigmentosum group C complementing factor
    xeroderma pigmentosum group C-like

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      15311510..15318239
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166087.2NP_725451.1  xeroderma pigmentosum, complementation group C, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725451.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24595
      Related
      FBpp0086505
      Conserved Domains (5) summary
      smart01032
      Location:11781252
      BHD_3; Rad4 beta-hairpin domain 3
      smart01030
      Location:10621112
      BHD_1; Rad4 beta-hairpin domain 1
      smart01031
      Location:11151170
      BHD_2; Rad4 beta-hairpin domain 2
      TIGR00605
      Location:3451294
      rad4; DNA repair protein rad4
      pfam03835
      Location:9251057
      Rad4; Rad4 transglutaminase-like domain
    2. NM_057513.4NP_476861.1  xeroderma pigmentosum, complementation group C, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476861.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24595, Q7KJI5, Q8MLA1, Q8MLA2, Q9U3Z0, Q9U3Z1, Q9V7A8
      Related
      FBpp0086506
      Conserved Domains (5) summary
      smart01032
      Location:11771251
      BHD_3; Rad4 beta-hairpin domain 3
      smart01030
      Location:10611111
      BHD_1; Rad4 beta-hairpin domain 1
      smart01031
      Location:11141169
      BHD_2; Rad4 beta-hairpin domain 2
      TIGR00605
      Location:3441293
      rad4; DNA repair protein rad4
      pfam03835
      Location:9241056
      Rad4; Rad4 transglutaminase-like domain
    3. NM_001259407.2NP_001246336.1  xeroderma pigmentosum, complementation group C, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246336.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K739, E3CTS1