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    Ssk Snakeskin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40207, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sskprovided by FlyBase
    Official Full Name
    Snakeskinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036945
    Locus tag
    Dmel_CG6981
    See related
    AllianceGenome:FB:FBgn0036945
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6981; CT21613; Dmel\CG6981; ssk
    Summary
    Involved in anterior midgut development and septate junction assembly. Located in apicolateral plasma membrane and smooth septate junction. Is expressed in Malpighian tubule; gut section; larval visceral muscle cell; and primordial germ cell. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ssk in Genome Data Viewer
    Location:
    77A1-77A1; 3-47 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20188522..20189779)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20181622..20182879)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45942 Neighboring gene uncharacterized protein Neighboring gene obstructor-F Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Compromised junctional integrity phenocopies age-dependent renal dysfunction in Drosophila Snakeskin mutants. Dornan AJ, et al. J Cell Sci, 2023 Oct 1. PMID 37694602, Free PMC Article
    2. Intestinal Snakeskin Limits Microbial Dysbiosis during Aging and Promotes Longevity. Salazar AM, et al. iScience, 2018 Nov 30. PMID 30419503, Free PMC Article
    3. Intestinal barrier dysfunction: an evolutionarily conserved hallmark of aging. Salazar AM, et al. Dis Model Mech, 2023 Apr 1. PMID 37144684, Free PMC Article
    4. Septate junctions regulate gut homeostasis through regulation of stem cell proliferation and enterocyte behavior in Drosophila. Izumi Y, et al. J Cell Sci, 2019 Sep 26. PMID 31444286
    5. The septate junction protein Tetraspanin 2A is critical to the structure and function of Malpighian tubules in Drosophila melanogaster. Beyenbach KW, et al. Am J Physiol Cell Physiol, 2020 Jun 1. PMID 32267718, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Snakeskin-Mesh Complex of Smooth Septate Junction Restricts Yorkie to Regulate Intestinal Homeostasis in Drosophila.
      Title: The Snakeskin-Mesh Complex of Smooth Septate Junction Restricts Yorkie to Regulate Intestinal Homeostasis in Drosophila.
    2. Together with Tsp2A, Ssk and Mesh form a protein complex, and all three proteins are required for smooth septate junctions (sSJs) formation, as well as intestinal barrier function.
      Title: Molecular dissection of smooth septate junctions: understanding their roles in arthropod physiology.
    3. Thus, a novel protein complex comprising Mesh and Ssk has an important role in sSJ formation and in intestinal barrier function in Drosophila
      Title: A novel protein complex, Mesh-Ssk, is required for septate junction formation in the Drosophila midgut.
    4. Ssk(CG6981) is required for the intestinal barrier function in Drosophila.
      Title: Snakeskin, a membrane protein associated with smooth septate junctions, is required for intestinal barrier function in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anterior midgut development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in septate junction assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in septate junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apicolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in smooth septate junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    snakeskin
    Names
    CG6981-PA
    CG6981-PB
    Ssk-PA
    Ssk-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      20188522..20189779
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168831.3 → NP_730487.1  snakeskin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730487.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D5A7R8, Q9VW87
      UniProtKB/TrEMBL
      A0A7G5X9Q9, A0A7G5X9R1, A0A7G5X9R3, A0A7G5X9R4, A0A7G5X9R8, C0MKE7
      Related
      FBpp0074589

    2. NM_140927.5 → NP_649184.1  snakeskin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649184.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D5A7R8, Q9VW87
      UniProtKB/TrEMBL
      A0A7G5X9Q9, A0A7G5X9R1, A0A7G5X9R3, A0A7G5X9R4, A0A7G5X9R8, C0MKE7
      Related
      FBpp0074590
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VW87.1 Q9VW87

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
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