Parp1 Poly-(ADP-ribose) polymerase 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Parp1provided by FlyBase
Official Full Name: Poly-(ADP-ribose) polymerase 1provided by FlyBase
Primary source: FLYBASE:FBgn0010247
Locus tag: Dmel_CG40411
See related: AllianceGenome:FB:FBgn0010247
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BEST:LD21673; CG17685; CG17696; CG17718; CG40411; D.PARP; dARTD1; Dm.pARTa; Dmel\CG40411; dmparp; dPARP; dParp1; dPARP1; LD21673.3prime; parp; Parp; PARP; parp-1; PARP-1; PARP1; PARPS-1
Summary: Enables NAD+-protein poly-ADP-ribosyltransferase activity; NAD+-protein-serine ADP-ribosyltransferase activity; and histone binding activity. Involved in several processes, including heat shock-mediated polytene chromosome puffing; nucleus organization; and positive regulation of defense response to bacterium. Located in chromosome and nuclear lumen. Is active in site of DNA damage. Is expressed in cercus; nurse cell; oocyte; organism; and presumptive embryonic/larval central nervous system. Human ortholog(s) of this gene implicated in several diseases, including arthritis; bacterial meningitis; neurodegenerative disease (multiple); stomach carcinoma; and type 2 diabetes mellitus. Orthologous to human PARP1 (poly(ADP-ribose) polymerase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 81F4-81F5; 3-47.1 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (3461351..3587054, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3RHet	NW_001848858.1 (1935206..2026815)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PARP-1 is a transcriptional rheostat of metabolic and bivalent genes during development.
Title: PARP-1 is a transcriptional rheostat of metabolic and bivalent genes during development.
Muscle PARP1 inhibition extends lifespan through AMPKalpha PARylation and activation in Drosophila.
Title: Muscle PARP1 inhibition extends lifespan through AMPKα PARylation and activation in Drosophila.
Early loss of endogenous NAD[+] following rotenone treatment leads to mitochondrial dysfunction and Sarm1 induction that is ameliorated by PARP inhibition.
Title: Early loss of endogenous NAD(+) following rotenone treatment leads to mitochondrial dysfunction and Sarm1 induction that is ameliorated by PARP inhibition.
Parp mutations protect from mitochondrial toxicity in Alzheimer's disease.
Title: Parp mutations protect from mitochondrial toxicity in Alzheimer's disease.
Poly(ADP-ribose) polymerase 1 in genome-wide expression control in Drosophila.
Title: Poly(ADP-ribose) polymerase 1 in genome-wide expression control in Drosophila.
PARP1 is a versatile factor in the regulation of mRNA stability and decay.
Title: PARP1 is a versatile factor in the regulation of mRNA stability and decay.
The long-term chromatin loosening required to sustain transcription takes place when the C-terminal domain of PARP-1 binds to chromatin by interacting with histone H4 in the nucleosome.
Title: Hit and run versus long-term activation of PARP-1 by its different domains fine-tunes nuclear processes.
The results demonstrate that PARylation process in Drosophila is tightly regulated in the context of strands-breaks repair; PARP is essential during the maintenance of DNA integrity, but dispensable in the DNA repair process.
Title: DNA maintenance following bleomycin-induced strand breaks does not require poly(ADP-ribosyl)ation activation in Drosophila S2 cells.
A mutation of Parp also increases NAD+ levels; although, this was only observed in parkin mutant flies and not in the heterozygous Parp mutants, possibly owing to an increased PARP activity in the parkin mutants.
Title: Parp mutations protect against mitochondrial dysfunction and neurodegeneration in a PARKIN model of Parkinson's disease.
chromatin loosening and associated initiation of gene expression is activated by phosphorylation of H2Av in a nucleosome positioned in promoter regions of PARP-1-dependent genes
Title: Kinase-mediated changes in nucleosome conformation trigger chromatin decondensation via poly(ADP-ribosyl)ation.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: c3510053-3508595 mobile_element_type = transposon:Tc1-2{}6592

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables NAD+-protein ADP-ribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+-protein ADP-ribosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables NAD+-protein poly-ADP-ribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+-protein poly-ADP-ribosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables NAD+-protein poly-ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables NAD+-protein poly-ADP-ribosyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables NAD+-protein-serine ADP-ribosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Cajal body organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA damage response	IDA Inferred from Direct Assay more info	PubMed
involved_in dorsal/ventral axis specification, ovarian follicular epithelium	IGI Inferred from Genetic Interaction more info	PubMed
involved_in double-strand break repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in heat shock-mediated polytene chromosome puffing	IEP Inferred from Expression Pattern more info	PubMed
involved_in heat shock-mediated polytene chromosome puffing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of protein location in nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleolus organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of antibacterial peptide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of peptidoglycan recognition protein signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to nucleolus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of RNA splicing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of chromatin organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ribosome biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Cajal body	IDA Inferred from Direct Assay more info	PubMed
located_in Cajal body	IMP Inferred from Mutant Phenotype more info	PubMed
located_in chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in euchromatin	IDA Inferred from Direct Assay more info	PubMed
located_in histone locus body	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in site of DNA damage	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Poly-(ADP-ribose) polymerase 1

Names: (Poly (ADP-ribose) polymeras; CG40411-PB; Parp1-PB; Poly(ADP ribose) polymerase 1; Poly(ADP)-Ribose polymerase; Poly(ADP-)Ribose polymerase; Poly(ADP-ribose) polymerase; Poly(ADP-ribose) polymerase 1; Poly-(ADP-ribose) polymerase; poly (ADP-ribose) polymerase; poly ADP ribose polymerase; poly ADP-ribose (ADPr) polymerase 1