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    Mf Myofilin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41824, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Mfprovided by FlyBase
    Official Full Name
    Myofilinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038294
    Locus tag
    Dmel_CG6803
    See related
    AllianceGenome:FB:FBgn0038294
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH23305; CG6803; Dmel\CG6803; DmMf; z1; Zeelin1
    Summary
    Located in A band. Is expressed in adult head; adult heart; larval muscle system; and larval somatic muscle cell. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    88E2-88E2; 3-56 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15170625..15181510, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (10996347..11007232, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45600 Neighboring gene uncharacterized protein Neighboring gene Glycogen synthase Neighboring gene Guanylyl cyclase at 88E Neighboring gene mir-3644 stem loop Neighboring gene Kip1 ubiquitination-promoting complex subunit 1 Neighboring gene uncharacterized protein Neighboring gene Serpin 88Ea

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Myofilin, a protein in the thick filaments of insect muscle. Qiu F, et al. J Cell Sci, 2005 Apr 1. PMID 15769842
    2. Structure of the Drosophila melanogaster Flight Muscle Myosin Filament at 4.7 Å Resolution Reveals New Details of Non-Myosin Proteins. Abbasi Yeganeh F, et al. Int J Mol Sci, 2023 Oct 5. PMID 37834384, Free PMC Article
    3. Matrix metalloproteinase 1 modulates invasive behavior of tracheal branches during entry into Drosophila flight muscles. Sauerwald J, et al. Elife, 2019 Oct 2. PMID 31577228, Free PMC Article
    4. CryoEM structure of Drosophila flight muscle thick filaments at 7 Å resolution. Daneshparvar N, et al. Life Sci Alliance, 2020 Aug. PMID 32718994, Free PMC Article
    5. dLin52 is crucial for dE2F and dRBF mediated transcriptional regulation of pro-apoptotic gene hid. Bhaskar PK, et al. Biochim Biophys Acta, 2014 Sep. PMID 24863159

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    located_in A band IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in striated muscle myosin thick filament HDA PubMed 

    General protein information

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    Preferred Names
    myofilin
    Names
    CG6803-PA
    CG6803-PB
    CG6803-PC
    CG6803-PD
    CG6803-PE
    CG6803-PF
    CG6803-PG
    CG6803-PH
    CG6803-PI
    CG6803-PJ
    CG6803-PK
    CG6803-PL
    CG6803-PM
    CG6803-PN
    CG6803-PO
    CG6803-PP
    CG6803-PQ
    Mf-PA
    Mf-PB
    Mf-PC
    Mf-PD
    Mf-PE
    Mf-PF
    Mf-PG
    Mf-PH
    Mf-PI
    Mf-PJ
    Mf-PK
    Mf-PL
    Mf-PM
    Mf-PN
    Mf-PO
    Mf-PP
    Mf-PQ
    zeelin
    zeelin1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15170625..15181510 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001170138.1 → NP_001163609.1  myofilin, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163609.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C1C553
      Conserved Domains (1) summary
      pfam15929
      Location:1 → 133
      Myofilin; Myofilin

    2. NM_001275656.1 → NP_001262585.1  myofilin, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262585.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KG65
      Conserved Domains (1) summary
      pfam15929
      Location:1 → 131
      Myofilin

    3. NM_169612.1 → NP_731969.1  myofilin, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731969.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8INF1
      Related
      FBpp0082493, FBtr0083034
      Conserved Domains (1) summary
      pfam15929
      Location:1 → 133
      Myofilin; Myofilin

    4. NM_001170140.1 → NP_001163611.1  myofilin, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163611.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JIK6
      Conserved Domains (1) summary
      pfam15929
      Location:1 → 133
      Myofilin; Myofilin

    5. NM_169613.1 → NP_731970.1  myofilin, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731970.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95U15
      Related
      FBpp0082492, FBtr0083033
      Conserved Domains (1) summary
      pfam15929
      Location:1 → 133
      Myofilin

    6. NM_001170142.1 → NP_001163613.1  myofilin, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163613.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C1C553
      Conserved Domains (1) summary
      pfam15929
      Location:1 → 133
      Myofilin; Myofilin

    7. NM_001260185.1 → NP_001247114.1  myofilin, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247114.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q70VI1
      Conserved Domains (1) summary
      pfam15929
      Location:1 → 133
      Myofilin; Myofilin

    8. NM_142166.2 → NP_650423.1  myofilin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650423.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SZ09, Q9VFC7
      Related
      FBpp0082490, FBtr0083031
      Conserved Domains (1) summary
      pfam15929
      Location:1 → 133
      Myofilin; Myofilin

    9. NM_001260184.1 → NP_001247113.1  myofilin, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247113.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q70VI1
      Conserved Domains (1) summary
      pfam15929
      Location:1 → 133
      Myofilin; Myofilin

    10. NM_001170141.1 → NP_001163612.1  myofilin, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163612.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JIK9
      Conserved Domains (1) summary
      pfam15929
      Location:1 → 133
      Myofilin

    11. NM_001300405.1 → NP_001287334.1  myofilin, isoform P [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287334.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C1C529
      Conserved Domains (1) summary
      pfam15929
      Location:1 → 97
      Myofilin; Myofilin

    12. NM_001300406.1 → NP_001287335.1  myofilin, isoform Q [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287335.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8I062
      Conserved Domains (1) summary
      pfam15929
      Location:1 → 133
      Myofilin

    13. NM_001275655.1 → NP_001262584.1  myofilin, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262584.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VFC6
      Conserved Domains (1) summary
      pfam15929
      Location:1 → 126
      Myofilin; Myofilin

    14. NM_001170139.1 → NP_001163610.1  myofilin, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163610.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VFC6
      Conserved Domains (1) summary
      pfam15929
      Location:1 → 126
      Myofilin; Myofilin

    15. NM_169614.2 → NP_731971.1  myofilin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731971.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VFC6
      Related
      FBpp0082489
      Conserved Domains (1) summary
      pfam15929
      Location:1 → 126
      Myofilin; Myofilin

    16. NM_169615.2 → NP_731972.1  myofilin, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731972.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8I062
      Related
      FBpp0082491
      Conserved Domains (1) summary
      pfam15929
      Location:1 → 133
      Myofilin

    17. NM_001260183.1 → NP_001247112.1  myofilin, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247112.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C1C529
      Conserved Domains (1) summary
      pfam15929
      Location:1 → 97
      Myofilin; Myofilin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KG65 A0A0B4KG65
    C1C529 C1C529
    C1C553 C1C553
    E1JIK6 E1JIK6
    E1JIK9 E1JIK9
    Q70VI1 Q70VI1
    Q70VI4 Q70VI4
    Q8I062 Q8I062
    Q8INF1 Q8INF1
    Q95U15 Q95U15
    Q9VFC6 Q9VFC6
    Q9VFC7 Q9VFC7

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