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    nur nemuri [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 318957, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nurprovided by FlyBase
    Official Full Name
    nemuriprovided by FlyBase
    Primary source
    FLYBASE:FBgn0051813
    Locus tag
    Dmel_CG31813
    See related
    AllianceGenome:FB:FBgn0051813
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE62259; BG:DS08249.4; CG31813; Dmel\CG31813
    Summary
    Involved in antimicrobial humoral response and sleep. Located in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See nur in Genome Data Viewer
    Location:
    34D1-34D1; 2-49 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13736138..13737030)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13736138..13737030)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Dpr-interacting protein kappa Neighboring gene Glycerophosphate oxidase 3 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45913 Neighboring gene long non-coding RNA:CR44846 Neighboring gene mir-1002 stem loop Neighboring gene mir-968 stem loop Neighboring gene Transmembrane 9 superfamily protein member 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A sleep-inducing gene, nemuri, links sleep and immune function in Drosophila. Toda H, et al. Science, 2019 Feb 1. PMID 30705188, Free PMC Article
    2. The NFκB Dif is required for behavioral and molecular correlates of sleep homeostasis in Drosophila. O'Hara MK, et al. Sleep, 2024 Aug 14. PMID 38629438,
    3. Ubiquitin proteasome system in circadian rhythm and sleep homeostasis: Lessons from Drosophila. Ukita Y, et al. Genes Cells, 2022 Jun. PMID 35438236, Free PMC Article
    4. The Regulation of Drosophila Sleep. Shafer OT, et al. Curr Biol, 2021 Jan 11. PMID 33434488
    5. Forward genetic approach for behavioral neuroscience using animal models. Funato H. Proc Jpn Acad Ser B Phys Biol Sci, 2020. PMID 31932526, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in antimicrobial humoral response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sleep IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nemuri
    Names
    CG31813-PA
    CG31813-PB
    nur-PA
    nur-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      13736138..13737030
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298977.1 → NP_001285906.1  nemuri, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285906.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IGM6, Q8IP68

    2. NM_165053.2 → NP_723832.1  nemuri, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723832.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IGM6, Q8IP68
      Related
      FBpp0080108
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IP68.1 Q8IP68

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