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    Fer2LCH Ferritin 2 light chain homologue [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44965, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fer2LCHprovided by FlyBase
    Official Full Name
    Ferritin 2 light chain homologueprovided by FlyBase
    Primary source
    FLYBASE:FBgn0015221
    Locus tag
    Dmel_CG1469
    See related
    AllianceGenome:FB:FBgn0015221
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    2LCH; anon-EST:ParkEST264; CG1469; Dmel\CG1469; Fe2LCH; Fer-H; fer2; Fer2; Fer2LC; fer2lch; FerLCH; l(3)00035; l(3)07016; l(3)j2A3; l(3)neo60; l(3)neo63; l(3)s2083; LCH
    Summary
    Enables ferrous iron binding activity. Involved in detoxification of iron ion and iron ion import across plasma membrane. Located in Golgi apparatus. Part of ferritin complex. Is expressed in several structures, including anterior-posterior subdivision of organism; circulatory system primordium; embryonic/larval hemocyte; epithelium; and mesoderm. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Fer2LCH in Genome Data Viewer
    Location:
    99F2-99F2; 3-100 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30387804..30390584)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26213526..26216306)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene headcase Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46114 Neighboring gene Ferritin 1 heavy chain homologue Neighboring gene long non-coding RNA:CR45570 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Behavioral decline and premature lethality upon pan-neuronal ferritin overexpression in Drosophila infected with a virulent form of Wolbachia. Kosmidis S, et al. Front Pharmacol, 2014. PMID 24772084, Free PMC Article
    2. Isolation and properties of Drosophila melanogaster ferritin--molecular cloning of a cDNA that encodes one subunit, and localization of the gene on the third chromosome. Charlesworth A, et al. Eur J Biochem, 1997 Jul 15. PMID 9266686
    3. Biophysical and genetic analysis of iron partitioning and ferritin function in Drosophila melanogaster. Gutiérrez L, et al. Metallomics, 2013 Aug. PMID 23771129
    4. Iron is a specific cofactor for distinct oxidation- and aggregation-dependent Aβ toxicity mechanisms in a Drosophila model. Ott S, et al. Dis Model Mech, 2015 Jul 1. PMID 26035384, Free PMC Article
    5. Iron availability dramatically alters the distribution of ferritin subunit messages in Drosophila melanogaster. Georgieva T, et al. Proc Natl Acad Sci U S A, 1999 Mar 16. PMID 10077577, Free PMC Article

    See all (113) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ferric iron binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ferric iron binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ferrous iron binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ferrous iron binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in detoxification of iron ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular iron ion homeostasis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intracellular iron ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in iron ion import across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in iron ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to fungus HEP PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endomembrane system HDA PubMed 
    located_in extracellular region HDA PubMed 
    part_of ferritin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ferritin 2 light chain homologue
    Names
    CG1469-PA
    CG1469-PB
    CG1469-PC
    CG1469-PD
    CG1469-PE
    Fer2LCH-PA
    Fer2LCH-PB
    Fer2LCH-PC
    Fer2LCH-PD
    Fer2LCH-PE
    Ferritin-Heavy
    Ferritin-Light
    Ferritin2
    ferritin
    ferritin 2 light chain
    ferritin 2 light chain homolog
    ferritin L
    ferritin LCH
    ferritin light chain
    ferritin-2 light chain homolog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      30387804..30390584
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080063.4 → NP_524802.2  ferritin 2 light chain homologue, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524802.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U4U2, Q9U7A3, Q9VA83
      Related
      FBpp0084986
      Conserved Domains (1) summary
      cd01056
      Location:51 → 223
      Euk_Ferritin; eukaryotic ferritins

    2. NM_170483.1 → NP_733362.1  ferritin 2 light chain homologue, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733362.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U4U2, Q9U7A3, Q9VA83
      Related
      FBpp0084987, FBtr0085623
      Conserved Domains (1) summary
      cd01056
      Location:51 → 223
      Euk_Ferritin; eukaryotic ferritins

    3. NM_001276177.1 → NP_001263106.1  ferritin 2 light chain homologue, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263106.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHF0
      Conserved Domains (1) summary
      cd01056
      Location:60 → 232
      Euk_Ferritin; eukaryotic ferritins

    4. NM_001276176.1 → NP_001263105.1  ferritin 2 light chain homologue, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263105.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U4U2, Q9U7A3, Q9VA83
      Conserved Domains (1) summary
      cd01056
      Location:51 → 223
      Euk_Ferritin; eukaryotic ferritins

    5. NM_170484.1 → NP_733363.1  ferritin 2 light chain homologue, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733363.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U4U2, Q9U7A3, Q9VA83
      Related
      FBpp0084988, FBtr0085624
      Conserved Domains (1) summary
      cd01056
      Location:51 → 223
      Euk_Ferritin; eukaryotic ferritins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KHF0 A0A0B4KHF0
    Q9U4U2 Q9U4U2
    Q9U7A3 Q9U7A3
    Q9VA83 Q9VA83
    Q9VA83.1

    Gene LinkOut

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