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    CG6927 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31419, updated on 17-Dec-2024

    Summary

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    Official Symbol
    CG6927provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029733
    Locus tag
    Dmel_CG6927
    See related
    AllianceGenome:FB:FBgn0029733
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CT21430; Dmel\CG6927; Lcch-4D
    Summary
    Enables pH-gated chloride channel activity. Predicted to be involved in chemical synaptic transmission; chloride transmembrane transport; and regulation of membrane potential. Predicted to be located in membrane. Predicted to be part of transmembrane transporter complex. Predicted to be active in neuron projection; plasma membrane; and synapse. Is expressed in adult optic lobe; antenna; and nurse cell. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG6927 in Genome Data Viewer
    Location:
    4D5-4D5; 1-9 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (4906900..4908821)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (4800933..4802854)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43495 Neighboring gene boilerman Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. secCl is a cys-loop ion channel necessary for the chloride conductance that mediates hormone-induced fluid secretion in Drosophila. Feingold D, et al. Sci Rep, 2019 May 16. PMID 31097722, Free PMC Article
    2. The orphan pentameric ligand-gated ion channel pHCl-2 is gated by pH and regulates fluid secretion in Drosophila Malpighian tubules. Feingold D, et al. J Exp Biol, 2016 Sep 1. PMID 27358471
    3. Evidence for a diverse Cys-loop ligand-gated ion channel superfamily in early bilateria. Dent JA. J Mol Evol, 2006 May. PMID 16586016
    4. Two cDNAs coding for histamine-gated ion channels in D. melanogaster. Gisselmann G, et al. Nat Neurosci, 2002 Jan. PMID 11753412
    5. A novel chloride channel in Drosophila melanogaster is inhibited by protons. Schnizler K, et al. J Biol Chem, 2005 Apr 22. PMID 15713676

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables excitatory extracellular ligand-gated monoatomic ion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables extracellular ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pH-gated chloride channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG6927-PA
    glycine-gated chloride channel-like

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      4906900..4908821
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_131966.2 → NP_572194.1  uncharacterized protein Dmel_CG6927 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572194.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W4G1
      Related
      FBpp0070689
      Conserved Domains (3) summary
      TIGR00860
      Location:3 → 520
      LIC; Cation transporter family protein
      pfam02931
      Location:36 → 259
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:270 → 518
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W4G1 Q9W4G1

    Gene LinkOut

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