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    l(3)neo43 lethal (3) neo43 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41851, updated on 9-Dec-2024

    Summary

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    Official Symbol
    l(3)neo43provided by FlyBase
    Official Full Name
    lethal (3) neo43provided by FlyBase
    Primary source
    FLYBASE:FBgn0011476
    Locus tag
    Dmel_CG14865
    See related
    AllianceGenome:FB:FBgn0011476
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14865; Dmel\CG14865
    Summary
    Predicted to be involved in mitochondrial cytochrome c oxidase assembly. Predicted to be located in mitochondrial membrane. Predicted to be active in mitochondrial inner membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 22. Orthologous to human COX16 (cytochrome c oxidase assembly factor COX16). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See l(3)neo43 in Genome Data Viewer
    Location:
    88E11-88E11; 3-56 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15277981..15278668, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11103703..11104390, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Zinc/iron regulated transporter-related protein 88E Neighboring gene Centrosomal protein 190kD Neighboring gene antisense RNA:CR46081 Neighboring gene uncharacterized protein Neighboring gene MORF-related gene 15 Neighboring gene Tropomyosin 1 Neighboring gene uncharacterized protein Neighboring gene Tropomyosin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila centrosome-associated protein CP190 is essential for viability but not for cell division. Butcher RD, et al. J Cell Sci, 2004 Mar 1. PMID 14996941
    2. Genetic and molecular analysis of region 88E9;88F2 in Drosophila melanogaster, including the ear gene related to human factors involved in lineage-specific leukemias. Zraly CB, et al. Genetics, 2002 Mar. PMID 11901121, Free PMC Article
    3. Insertional mutagenesis of the Drosophila genome with single P elements. Cooley L, et al. Science, 1988 Mar 4. PMID 2830671
    4. Ultra-deep sequencing of ribosome-associated poly-adenylated RNA in early Drosophila embryos reveals hundreds of conserved translated sORFs. Li H, et al. DNA Res, 2016 Dec. PMID 27559081, Free PMC Article
    5. Transcriptome analysis of FOXO-dependent hypoxia gene expression identifies Hipk as a regulator of low oxygen tolerance in Drosophila. Ding K, et al. G3 (Bethesda), 2022 Dec 1. PMID 36200850, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mitochondrial cytochrome c oxidase assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial cytochrome c oxidase assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lethal (3) neo43
    Names
    CG14865-PD
    CG14865-PE
    l(3)neo43-PD
    l(3)neo43-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15277981..15278668 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275660.2 → NP_001262589.2  lethal (3) neo43, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1B2AKH8, A8E6N3, Q29QH7, Q9VF98
      Conserved Domains (1) summary
      pfam14138
      Location:16 → 94
      COX16; Cytochrome c oxidase assembly protein COX16

    2. NM_142186.3 → NP_650443.3  lethal (3) neo43, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1B2AKH8, A8E6N3, Q29QH7, Q9VF98
      Conserved Domains (1) summary
      pfam14138
      Location:16 → 94
      COX16; Cytochrome c oxidase assembly protein COX16
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VF98 Q9VF98

    Gene LinkOut

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