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    Sec61alpha Sec61 alpha subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33905, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sec61alphaprovided by FlyBase
    Official Full Name
    Sec61 alpha subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0086357
    Locus tag
    Dmel_CG9539
    See related
    AllianceGenome:FB:FBgn0086357
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    0455; anon-WO0118547.195; anon-WO0118547.277; BcDNA:LD29847; BEST:LD29847; CG9539; Dmel\CG9539; dSEC61A; dSec61alpha; DSec61alpha; E(br)165; endd2; l(2)k04917; LD29847; sec61; Sec61; Sec61-alpha; SEC61-alpha; Sec61a; sec61alpha; SEC61ALPHA
    Summary
    Predicted to enable protein transmembrane transporter activity; ribosome binding activity; and signal sequence binding activity. Involved in several processes, including embryonic development via the syncytial blastoderm; positive regulation of iron ion transmembrane transport; and positive regulation of viral entry into host cell. Located in fusome and rough endoplasmic reticulum. Is expressed in several structures, including adult brain cell body rind; adult gnathal ganglion; epidermis; female germline cell; and gut section. Human ortholog(s) of this gene implicated in common variable immunodeficiency; familial juvenile hyperuricemic nephropathy; and severe congenital neutropenia. Orthologous to human SEC61A1 (SEC61 translocon subunit alpha 1) and SEC61A2 (SEC61 translocon subunit alpha 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Sec61alpha in Genome Data Viewer
    Location:
    26D7-26D8; 2-20 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6477182..6480575, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6477182..6480575, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene mummy Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45463 Neighboring gene Daxx-like protein Neighboring gene Kynurenine formamidase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The fusome mediates intercellular endoplasmic reticulum connectivity in Drosophila ovarian cysts. Snapp EL, et al. Mol Biol Cell, 2004 Oct. PMID 15292454, Free PMC Article
    2. Cytosol-endoplasmic reticulum interplay by Sec61alpha translocon in polyglutamine-mediated neurotoxicity in Drosophila. Kanuka H, et al. Proc Natl Acad Sci U S A, 2003 Sep 30. PMID 14504396, Free PMC Article
    3. Genome-wide RNAi screen identifies SEC61A and VCP as conserved regulators of Sindbis virus entry. Panda D, et al. Cell Rep, 2013 Dec 26. PMID 24332855, Free PMC Article
    4. Pelota controls self-renewal of germline stem cells by repressing a Bam-independent differentiation pathway. Xi R, et al. Development, 2005 Dec. PMID 16280348
    5. Sec61alpha is required for dorsal closure during Drosophila embryogenesis through its regulation of Dpp signaling. Wang X, et al. Dev Dyn, 2010 Mar. PMID 20112345, Free PMC Article

    See all (78) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. dorsal closure is rescued in Sec61alpha mutant embryos by an activated form of the Dpp receptor Thick veins
      Title: Sec61alpha is required for dorsal closure during Drosophila embryogenesis through its regulation of Dpp signaling.
    2. Loss-of-function experiments for DSec61alpha revealed that the translocon contributes to expanded polyglutamine-mediated neuronal toxicity
      Title: Cytosol-endoplasmic reticulum interplay by Sec61alpha translocon in polyglutamine-mediated neurotoxicity in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signal sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in SRP-dependent cotranslational protein targeting to membrane, translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to virus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cuticle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal closure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in head involution IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of iron ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of viral entry into host cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in post-translational protein targeting to membrane, translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Sec61 translocon complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endomembrane system HDA PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in fusome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in rough endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Sec61 alpha subunit
    Names
    CG9539-PA
    CG9539-PB
    E(br)165
    Sec61alpha-PA
    Sec61alpha-PB
    effector for neural death and degeneration 2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6477182..6480575 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298745.1 → NP_001285674.1  Sec61 alpha subunit, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285674.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F0JAP1, Q8STG9, Q9VMD1
      Conserved Domains (1) summary
      PTZ00219
      Location:1 → 469
      PTZ00219; Sec61 alpha subunit; Provisional

    2. NM_135190.5 → NP_609034.1  Sec61 alpha subunit, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609034.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F0JAP1, Q8STG9, Q9VMD1
      Related
      FBpp0078896
      Conserved Domains (1) summary
      PTZ00219
      Location:1 → 469
      PTZ00219; Sec61 alpha subunit; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8STG9 Q8STG9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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