U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Diedel diedel [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43474, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Diedelprovided by FlyBase
    Official Full Name
    diedelprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039666
    Locus tag
    Dmel_CG11501
    See related
    AllianceGenome:FB:FBgn0039666
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RH38110; CG11501; die; Die; diedel; Dmel\CG11501
    Summary
    Enables cytokine activity. Involved in defense response to virus and response to bacterium. Located in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Diedel in Genome Data Viewer
    Location:
    99B1-99B1; 3-99 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29493852..29494267)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25319574..25319989)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Spase 12-subunit Neighboring gene uncharacterized protein Neighboring gene F-box involved in polyQ pathogenesis Neighboring gene TRC8 ring finger protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. WntD and Diedel: Two immunomodulatory cytokines in Drosophila immunity. Lamiable O, et al. Fly (Austin), 2016 Oct. PMID 27314646, Free PMC Article
    2. cGAS-like receptor-mediated immunity: the insect perspective. Cai H, et al. Curr Opin Immunol, 2022 Feb. PMID 35149240
    3. Integrin-ECM interactions and membrane-associated Catalase cooperate to promote resilience of the Drosophila intestinal epithelium. Mlih M, et al. PLoS Biol, 2022 May. PMID 35522719, Free PMC Article
    4. Pleiotropy of the Drosophila JAK pathway cytokine Unpaired 3 in development and aging. Wang L, et al. Dev Biol, 2014 Nov 15. PMID 25245869
    5. Actin is an evolutionarily-conserved damage-associated molecular pattern that signals tissue injury in Drosophila melanogaster. Srinivasan N, et al. Elife, 2016 Nov 22. PMID 27871362, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Diedel is an inhibitor of apoptosis and can act as a systemic rheostat to modulate cell death during aging.
      Title: A virus-acquired host cytokine controls systemic aging by antagonizing apoptosis.
    2. Study established that WntD and Die are 2 cytokines that regulate independently the expression of edin during infection by an intracellular bacteria and a virus, respectively.
      Title: WntD and Diedel: Two immunomodulatory cytokines in Drosophila immunity.
    3. die mutant flies have shortened lifespan and succumb more rapidly than controls when infected with Sindbis virus.
      Title: Cytokine Diedel and a viral homologue suppress the IMD pathway in Drosophila.
    4. Diedel, a marker of the Drosophila antimicrobial/antiviral response, is a member of a small family of proteins present in drosophilids, aphids and DNA viruses infecting lepidopterans
      Title: Crystal structure of Diedel, a marker of the immune response of Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cytokine activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    diedel
    Names
    CG11501-PA
    Diedel-PA

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      29493852..29494267
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143438.3 → NP_651695.1  diedel [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651695.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VAK8
      UniProtKB/TrEMBL
      A0A1B2AJC0
      Related
      FBpp0084794
      Conserved Domains (1) summary
      pfam13164
      Location:27 → 100
      DUF4002; Protein of unknown function (DUF4002)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VAK8.1 Q9VAK8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools