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    Cht7 Chitinase 7 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38370, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cht7provided by FlyBase
    Official Full Name
    Chitinase 7provided by FlyBase
    Primary source
    FLYBASE:FBgn0035398
    Locus tag
    Dmel_CG1869
    See related
    AllianceGenome:FB:FBgn0035398
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1869; Cht; cht7; DmCht7; DmCHT7; Dmel\CG1869
    Summary
    Enables chitinase activity. Involved in several processes, including chitin catabolic process; ecdysis, chitin-based cuticle; and regulation of tube architecture, open tracheal system. Predicted to be active in extracellular region. Is expressed in adult head. Human ortholog(s) of this gene implicated in asthma and schizophrenia. Orthologous to several human genes including CHIA (chitinase acidic). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Cht7 in Genome Data Viewer
    Location:
    63B1-63B1; 3-6 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3090985..3106958, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3090985..3106958, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Poly(A) specific ribonuclease subunit PAN3 Neighboring gene small nuclear RNA U5 at 63BC Neighboring gene transfer RNA:Cysteine-GCA 1-1 Neighboring gene transfer RNA:Lysine-CTT 1-12 Neighboring gene transfer RNA:Cysteine-GCA 1-2 Neighboring gene transfer RNA:Lysine-CTT 1-13 Neighboring gene transfer RNA:Cysteine-GCA 1-3 Neighboring gene transfer RNA:Cysteine-GCA 1-4 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene prominin-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Prenatal hyperbaric normoxia treatment improves healthspan and regulates chitin metabolic genes in Drosophila melanogaster. Yu S, et al. Aging (Albany NY), 2016 Oct 24. PMID 27777382, Free PMC Article
    2. Chitinase 10 controls chitin amounts and organization in the wing cuticle of Drosophila. Dong W, et al. Insect Sci, 2020 Dec. PMID 32129536
    3. Characterization of recombinant chitinase-like proteins of Drosophila melanogaster and Tribolium castaneum. Zhu Q, et al. Insect Biochem Mol Biol, 2008 Apr. PMID 18342251
    4. Involvement of mind the gap in the organization of the tracheal apical extracellular matrix in Drosophila and Nilaparvata lugens. Yue XZ, et al. Insect Sci, 2020 Aug. PMID 31240817
    5. Computational identification of novel chitinase-like proteins in the Drosophila melanogaster genome. Zhu Q, et al. Bioinformatics, 2004 Jan 22. PMID 14734306

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chitinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chitin catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chitin catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chitin-based cuticle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ecdysis, chitin-based cuticle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of tube architecture, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in wound healing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    chitinase 7
    Names
    CG1869-PA
    Cht7-PA
    NP_647768.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      3090985..3106958 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139511.4 → NP_647768.3  chitinase 7 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647768.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960M0, Q9VZV2
      Conserved Domains (3) summary
      cd02872
      Location:125 → 491
      GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
      smart00636
      Location:124 → 468
      Glyco_18; Glyco_18 domain
      pfam01607
      Location:951 → 1005
      CBM_14; Chitin binding Peritrophin-A domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VZV2 Q9VZV2

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