stc shuttle craft [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: stcprovided by FlyBase
Official Full Name: shuttle craftprovided by FlyBase
Primary source: FLYBASE:FBgn0001978
Locus tag: Dmel_CG3647
See related: AllianceGenome:FB:FBgn0001978
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 151662_s_at; BcDNA.LD22726; BcDNA:LD22726; BG:DS04929.4; br33; Cf4; CG3647; Dmel\CG3647; l(2)35Cb; l(2)br33; l(2)SH1565; l(2)SH2 1565; l35Cb; LD22726
Summary: Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; ubiquitin protein ligase activity; and zinc ion binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and protein autoubiquitination. Located in nucleus. Is expressed in several structures, including germline cell; larval brain; ovary; and presumptive embryonic/larval central nervous system. Orthologous to human NFX1 (nuclear transcription factor, X-box binding 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 35C2-35C2; 2-51 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (15113480..15118069)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (15113480..15118069)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Shuttle craft Gene Affects Lifespan of Drosophila melanogaster by Controlling Early Development and Modifying Aging Program.
Title: Shuttle craft Gene Affects Lifespan of Drosophila melanogaster by Controlling Early Development and Modifying Aging Program.
Shuttle craft regulates development of the nervous system and might also influence longevity in female drosophila.
Title: Embryonic expression of shuttle craft, a Drosophila gene involved in neuron development, is associated with adult lifespan.
Molecular variation of the shuttle craft and Lim3 genes, controlling the development of the nervous system, in a natural Drosophila melanogaster population
Title: [Molecular variation of the shuttle craft and Lim3 genes, controlling the development of the nervous system, in a natural Drosophila melanogaster population].

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0009 (e-PCR)
- UniSTS:12229

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISM Inferred from Sequence Model more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein autoubiquitination	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: shuttle craft

Names: CG3647-PA; CG3647-PB; CG3647-PC; CG3647-PD; Chorion-factor-4; shuttlecraft; stc-PA; stc-PB; stc-PC; stc-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

15113480..15118069

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057251.4 → NP_476599.1 shuttle craft, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476599.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P40798, Q8IP49, Q9VJQ1, Q9Y0Z5

Related

FBpp0080265

Conserved Domains (2) summary

cd02643
Location:996 → 1069

R3H_NF-X1; R3H domain of the X1 box binding protein (NF-X1) and related proteins. Human NF-X1 is a transcription factor that regulates the expression of class II major histocompatibility complex (MHC) genes. The Drosophila homolog shuttle craft (STC) has been shown ...

cd06008
Location:517 → 565

NF-X1-zinc-finger; Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger ...
NM_001273532.1 → NP_001260461.1 shuttle craft, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260461.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PD57

Conserved Domains (2) summary

cd02643
Location:992 → 1065

R3H_NF-X1; R3H domain of the X1 box binding protein (NF-X1) and related proteins. Human NF-X1 is a transcription factor that regulates the expression of class II major histocompatibility complex (MHC) genes. The Drosophila homolog shuttle craft (STC) has been shown ...

cd06008
Location:513 → 561

NF-X1-zinc-finger; Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger ...
NM_057250.4 → NP_476598.1 shuttle craft, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476598.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P40798

Related

FBpp0080266

Conserved Domains (2) summary

cd02643
Location:989 → 1062

R3H_NF-X1; R3H domain of the X1 box binding protein (NF-X1) and related proteins. Human NF-X1 is a transcription factor that regulates the expression of class II major histocompatibility complex (MHC) genes. The Drosophila homolog shuttle craft (STC) has been shown ...

cd06008
Location:510 → 558

NF-X1-zinc-finger; Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger ...
NM_001273531.1 → NP_001260460.1 shuttle craft, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260460.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PDG3

Conserved Domains (2) summary

cd02643
Location:985 → 1058

R3H_NF-X1; R3H domain of the X1 box binding protein (NF-X1) and related proteins. Human NF-X1 is a transcription factor that regulates the expression of class II major histocompatibility complex (MHC) genes. The Drosophila homolog shuttle craft (STC) has been shown ...

cd06008
Location:506 → 554

NF-X1-zinc-finger; Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger ...