sip3 septin interacting protein 3 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: sip3provided by FlyBase
Official Full Name: septin interacting protein 3provided by FlyBase
Primary source: FLYBASE:FBgn0039875
Locus tag: Dmel_CG1937
See related: AllianceGenome:FB:FBgn0039875
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG1937; dHRD1; Dmel\CG1937; dSyno; hrd1; Hrd1; HRD1; Sip3
Summary: Enables p53 binding activity and ubiquitin protein ligase activity. Involved in several processes, including endoplasmic reticulum unfolded protein response; intestinal stem cell homeostasis; and regulation of protein metabolic process. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum quality control compartment. Is expressed in several structures, including adult head; foregut primordium; gland; gut section; and salivary gland body primordium. Orthologous to human SYVN1 (synoviolin 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (31772219..31775163)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (27597941..27600885)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables p53 binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	ISM Inferred from Sequence Model more info	PubMed

Process	Evidence Code	Pubs
involved_in ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ERAD pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in endoplasmic reticulum unfolded protein response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intestinal stem cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ubiquitin-dependent protein catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of translation in response to endoplasmic reticulum stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to endoplasmic reticulum stress	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
is_active_in endoplasmic reticulum quality control compartment	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISM Inferred from Sequence Model more info	PubMed

Names: CG1937-PA; CG1937-PB; septin-interacting protein 3; sip3-PA; sip3-PB; synoviolin

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